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| LOSS OF HETEROZYGOSITY INVOLVING THE APC TUMOR SUPPRESSOR GENE IN HUMAN COLORECTAL CARCINOMA | |
| 引用本文： | 徐文怀,杨定成. LOSS OF HETEROZYGOSITY INVOLVING THE APC TUMOR SUPPRESSOR GENE IN HUMAN COLORECTAL CARCINOMA[J]. 中国癌症研究, 1995, 7(1): 51-54. DOI: 10.1007/BF02954708 |
| 作者姓名： | 徐文怀 杨定成 |
| 作者单位： | Department of Surgery，The First Clinical School，BeiJing Medical University，Beijing 100034 |
| 摘 要： | ＬＯＳＳＯＦＨＥＴＥＲＯＺＹＧＯＳＩＴＹＩＮＶＯＬＶＩＮＧＴＨＥＡＰＣＴＵＭＯＲＳＵＰＰＲＥＳＳＯＲＧＥＮＥＩＮＨＵＭＡＮＣＯＬＯＲＥＣＴＡＬＣＡＲＣＩＮＯＭＡ￥ＸｕＷｅｎｈｕａｉ；徐文怀；ＹａｎｇＤｉｎｇｃｈｅｎｇ；杨定成（Ｄｅｐａｒｔｍｅｎｔｏｆ... |
Loss of heterozygosity involving the APC tumor suppressor gene in human colorectal carcinoma |
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| Wenhuai Xu,Dingcheng Yang. Loss of heterozygosity involving the APC tumor suppressor gene in human colorectal carcinoma[J]. Chinese Journal of Cancer Research, 1995, 7(1): 51-54. DOI: 10.1007/BF02954708 | |
| Authors: | Wenhuai Xu Dingcheng Yang |
| Affiliation: | 1. Department of Surgery, The First Clinical School, Beijing Medical University, 100034, Beijing |
| Abstract: | To investigate whether aberration of the APC gene play any role in the development of Chinese sporadic colorectal carcinomas,we used a polymorphic site located in exon 11 which creted a new restriction site for RsaI to analyze LOH for the APC gene.We found that 20/29(68.9%) patients with colorectal cancer were informative for the APC exon 11 site and loss of one allele was detected in 40% of 20 informativc cascs.These data suggested that loss of heterozygosity of APC gene(APC-LOH) play a role in the pathogenesis of Chinese colorectal cancer.APC-LOH is a earlier event of colorectal tumorigenesis and may be of diagnostic value in Patient suffering colorectal cancer. |
| Keywords: | Heterozygosity APC gene Human colorectal carcinoma. |
| 本文献已被 CNKI SpringerLink 等数据库收录！ | |