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Repeated influenza vaccination induces similar immune protection as first-time vaccination but with differing immune responses
Authors:Beiwei Ye  Liumei Shu  Yuanyuan Pang  Yaxin Guo  Yuanyuan Guo  Kexin Zong  Cong Chen  Xianzhi Zheng  Jie Zhang  Maoshun Liu  Xiaoju Yuan  Yingze Zhao  Danni Zhang  Dayan Wang  Changjun Bao  Jun Zhang  Liling Chen  George F. Gao  William J. Liu
Affiliation:1. NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing, China;2. Department of Health Care, Beijing Daxing District Hospital, Beijing, China

Contribution: ​Investigation (equal), Methodology (equal), Project administration (equal);3. Suzhou Municipal Center for Disease Control and Prevention, Suzhou, Jiangsu, China

Contribution: ​Investigation (equal), Resources (equal);4. NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing, China

Contribution: Formal analysis (equal), ​Investigation (equal);5. NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing, China

Department of Epidemiology, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China

Contribution: ​Investigation (equal);6. NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing, China

Contribution: ​Investigation (equal);7. Changzhou Center for Disease Control and Prevention, Changzhou, Jiangsu, China

Contribution: ​Investigation (equal);8. School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China

Contribution: ​Investigation (equal);9. NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing, China

Contribution: Project administration (equal);10. Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, Jiangsu, China

Contribution: Resources (equal);11. Suzhou Municipal Center for Disease Control and Prevention, Suzhou, Jiangsu, China

Contribution: Resources (equal);12. Suzhou Municipal Center for Disease Control and Prevention, Suzhou, Jiangsu, China

Abstract:
Keywords:HAI titers  immune protection  influenza  repeated vaccination  vaccines
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