化工人群幽门螺杆菌感染与胃癌关系的探讨

目的 通过：（１）幽门螺杆菌（ＨＰ）感染的流行病学调查；（２）ＨＰ感染与胃癌前病变的关系；（３）ＨＰ在胃窦癌中的检出率三个方面来评价ＨＰ感染与胃癌的相关性。方法 分别为：（１）随机对南化公司２８４１名健康工人的血清作ＨＰ抗体测定；（２）将胃镜检查的６４８例作ＨＰ检测和病理组织学检查；（３）对５０例胃窦腺癌病理组织学切片鉴定基ＨＰ检出率。结果 化工人群ＨＰ感染率６１．０４％，显著高于本省对照人群（３

Study on relationship between helicobactor pylori infection and gastric cancer in employees of chemical factory

Objective Assessment was made of : (1) epidemiology of helicobacter pylori (Hp) infection; (2) the relation of Hp infection to gastric precancerous disorders; (3) Hp detection rate in gastric antral cancer Methods Respectively (1) serum for Hp antibody was tested at random in 2841 members of staff in the Nanjing chemical industry group company during annual health check-up; (2) helicobacter pylori was assayed with rapid urease test and histopathology in 648 patients undergoing gastroscopy; (3) the pathology of resected specimen was reviewed to detect Hp in 50 cases with gastric antral carcinoma Results The rate of Hp infection in the enterprise rose to 61 04 percent, significantly higher than that in local population (32 84%) The incidence of precancerous lesion in patients with Hp elevated evidently In 58 percent of gastric antral adenocarcinoma Hp could be found Conclusion Hp infection is assumed as an essential factor in gastric cancer in employees of chemical factory