重症急性胰腺炎并发肝功能不全的临床研究

目的:探讨重症急性胰腺炎(severeacutepancreatitis,SAP)并发肝功能不全的发病因素、预后和防治措施。方法:回顾分析2003年1月~2004年6月我院收治的152例SAP患者,其中67例并发肝功能不全,85例不伴有肝功能不全。对比分析两组患者的病因、血液生化指标、并发症、病程及病死率等相关因素。结果:SAP肝功能不全组的病因中胆源性疾病明显高于SAP非肝功能不全组(P<0.01);其血清淀粉酶、肌酐、乳酸脱氢酶水平均高于SAP非肝功能不全组(P<0.05);其肾功能衰竭、心功能衰竭、消化道出血、感染的发生率亦均高于SAP非肝功能不全组(P<0.05)。两组之间病死率的比较无统计学差异。SAP肝功能不全组的病程较SAP非肝功能不全组长,差异有统计学意义(P<0.05)。结论:SAP合并肝功能不全与SAP所引起的机体内环境紊乱及肝脏自身的功能特点有关。控制胆源性疾病、积极的中药干预、尽快恢复肠道功能、减少胰酶的破坏、稳定内环境以及避免使用具有肝脏毒性的药物,对于降低肝功能不全的发生率有重要意义。

Clinical study on severe acute pancreatitis complicated by hepatic insufficiency

Objective: To investigate the pathogenic factors of severe acute pancreatitis (SAP) complicated by hepatic insufficiency, the prognosis and the effective preventive and therapeutic interventions. Methods: One hundred and fifty-two patients with SAP (from January 2003 to June 2004) were divided into 2 groups, SAP with hepatic insufficiency group and SAP without hepatic insufficiency group. The related factors such as causes of disease, serum biochemical criteria, complications, mortality and course of disease were observed. Results: The concentrations of serum amylase, creatinine and lactate dehydrogenase were all much higher in the SAP with hepatic insufficiency group than those in the SAP without hepatic insufficiency group (P<0.05). The incidences of complications such as acute renal failure, heart failure, gastrointestinal hemorrhage and infection were also higher in the SAP with hepatic insufficiency group than those in the SAP without hepatic insufficiency group (P<0.05). There was no significant difference in mortality between these two groups, but the course of disease in SAP with hepatic insufficiency group was longer than that in the other group (P<0.05). Conclusion: The causes of SAP complicated by hepatic insufficiency are related to the imbalance of internal environment and the characteristics of the liver function. To control the biliary tract diseases, intervene with traditional Chinese medicine, recover the intestinal function in time, reduce the damage of pancreatic enzyme, maintain the stability of internal environment and avoid using drugs that can induce liver injury are all important aspects of reducing the incidence of hepatic insufficiency.