妇科恶性肿瘤患者凝血功能变化及其临床意义

目的：研究妇科恶性肿瘤患者5项凝血指标的变化及其临床意义。方法：术前测定101例妇科恶性肿瘤患者（宫颈癌28例,卵巢癌35例,子宫内膜癌38例）的血小板（PLT）、血浆凝血酶原时间（PT）、部分凝血活酶时间（APTT）、凝血酶时间（TT）、纤维蛋白原（FIB）并与89例妇科良性肿瘤患者（子宫肌瘤45例,卵巢囊肿44例）进行比较。结果：妇科恶性肿瘤患者的FIB及PLT水平与妇科良性肿瘤组相比明显增高（P〈0.01）;而APTT、PT、TT水平与妇科良性肿瘤组相比差异无统计学意义（P〉0.05）,同时分期为Ⅲ～Ⅳ期晚期恶性肿瘤患者的血浆FIB及PLT水平均高于Ⅰ～Ⅱ期的患者（P〈0.01）。结论：妇科恶性肿瘤患者体内存在着异常的血液高凝状态。

The changes of coagulation function and its clinical significance in patients with gynecologic malignant tumor

Objective： To study the changs of coagulation parameter in patients with gynecologic malignant tumor and its clinical significance.Methods： Detect the PLT,PT,APTT,TT and FIB levels of 101 gynecologic malignan tumors（including 28 cervical carcinomas,35 ovarian carcinomas,38 uterus intimal carcinomas） and 89 gynecologic tumors（inciuding 45 uterine myomas,44 oarian cysts）.Results： As compared with normal terms,APTT,PT and TT were no significanty different while FIB and PLT were significantly higher（P〈0.01）in gynecologic malignant tumor patients.FIB and PLT of term Ⅲ to Ⅳ were higher than that in term Ⅰ to Ⅱ（P〈0.01）.Conclusion： There are an abnomal balance between hyper-coagulation in patients with gynecologic malignant tumor.