DTI和T1WI测值法在早产儿脑发育评估中的应用价值

目的:探讨磁共振扩散张量成像(DTI)和T1WI测值法在早产儿脑发育评估中的应用价值.方法:将32例早产儿根据分娩孕周分为早期早产儿组(出生胎龄≤32周,19例)和中晚期早产儿组(出生胎龄>32周,13例),均进行DTI检查,测量感兴趣区(ROI)的各向异性分数(FA)值和表观扩散系数(ADC)值.ROI包括胼胝体压部...

Application of diffusion tensor imaging and T1 WI value measurement on white matter development in preterm infants

Objective:To explore the application of diffusion tensor imaging(DTI)and T₁WI value measurement on white matter development in preterm infants.Methods:According to Gestational age(GA),32 preterm infants were divided into two groups:early preterm infant group(GA≤32 weeks,n=19)and mid-late preterm infant group(GA>32 weeks,n=13).Diffusion tensor imaging and T₁WI were performed.The fractional anisotropy(FA),apparent diffusion coefficient(ADC)and T₁WI signal value of rregion of interest(ROI)were measured.ROI were set on the knees of the the corpus callosum,the splenium of the corpus callosum,bilateral peri-ventricles posterior horns,the posterior limbs of the bilateral internal capsule,and bilateral centrum semi-ovale.Differences of FA and ADC value between two groups were analyzed to evaluate the effect of GA week on brain white matter development in premature infants.Results:Compared with mid-late preterm infant group,the FA value of corpus callosum knee and corpus callosum in the early preterm infant group was lower,and ADC value was higher.The difference between the two groups had statistical significance(P<0.05).There was no statistical difference in T₁WI signal value between the two groups of all ROI(P>0.05).Conclusion:DTI method and T₁WI signal value measurements can monitor the development of white matter in premature infants,especially FA value is of the most sensitive.Compared with the mid-late preterm infants,white matter myelinations in early preterm infants are relatively lagging behind.