| 中药异位宁对子宫内膜异位症模型大鼠Fas/FasL基因表达影响的实验研究 |
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| 引用本文： | 马文光,徐晓宇,谭文华,曲凡,马宝璋. 中药异位宁对子宫内膜异位症模型大鼠Fas/FasL基因表达影响的实验研究[J]. 中华中医药杂志, 2007, 22(12): 879-881 |
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| 作者姓名： | 马文光 徐晓宇 谭文华 曲凡 马宝璋 |
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| 作者单位： | 1. 黑龙江中医药大学,哈尔滨,150040
2. 哈尔滨医科大学附属第二医院,哈尔滨,150080 |
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| 基金项目： | 黑龙江省自然科学基金;国家教育部高等学校博士学科点专题科研基金 |
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| 摘 要： | 目的：通过研究异位宁对Fas/FasL蛋白表达的影响来阐述异位宁治疗子宫内膜异位症的作用机制。方法：取雌性Wistar大鼠,随机分为5组,正常对照组、模型对照组、异位宁高、低剂量组及西药丹那唑对照组;造模成功后各给药组灌胃给药1个月后,观察各组子宫内膜局部组织中Fas及FasL蛋白的表达情况。结果：治疗后异位宁高、低剂量组以及西药对照组Fas、FasL表达增多,染色较深,与模型组比较有显著性差异（P〈0.05）。结论：异位宁具有诱导Fas、FasL基因表达,提高异位内膜凋亡能力,使异位病灶得以萎缩、消失的作用。
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| 关 键 词： | 子宫内膜异位症 中药异位宁 蛋白表达 凋亡基因 实验研究 |
| 收稿时间： | 2007-05-15 |
| 修稿时间： | 2007-05-15 |
Empirical study of effect of Yiwei Ning on expression of Fas/FasL in rat with endometriosis |
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| MA Wen-guang,XU Xiao-yu,TAN Wen-hua,QU Fan,MA Bao-zhang. Empirical study of effect of Yiwei Ning on expression of Fas/FasL in rat with endometriosis[J]. China Journal of Traditional Chinese Medicine and Pharmacy, 2007, 22(12): 879-881 |
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| Authors: | MA Wen-guang XU Xiao-yu TAN Wen-hua QU Fan MA Bao-zhang |
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| Abstract: | Objective: To expound the effect of Yiwei Ning in treating endometriosis through measuring Fas/FasL protein expression.Method:The female Wistar rats were divided into five groups randomly.After 8 weeks of administration,expression of Fas/FasL protein were determined.Results: There were significant difference in the positive expression of Fas/FasL protein between Yiwei Ning group and the control group(P<0.05).Conclusion: Yiwei Ning could induce the expression of Fas/FasL gene,facilitate the cell apoptosis of the ectopic endometrium,which make the ectopic endometrium atrophy and disappear. |
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| Keywords: | Fas/FasL |
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