Recent Perspectives in Ocular Drug Delivery |
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Authors: | Ripal Gaudana J Jwala Sai H S Boddu Ashim K Mitra |
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Institution: | (1) Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, 5005 Rockhill Road, Kansas City, Missouri 64110-2499, USA |
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Abstract: | Anatomy and physiology of the eye makes it a highly protected organ. Designing an effective therapy for ocular diseases, especially
for the posterior segment, has been considered as a formidable task. Limitations of topical and intravitreal route of administration
have challenged scientists to find alternative mode of administration like periocular routes. Transporter targeted drug delivery
has generated a great deal of interest in the field because of its potential to overcome many barriers associated with current
therapy. Application of nanotechnology has been very promising in the treatment of a gamut of diseases. In this review, we
have briefly discussed several ocular drug delivery systems such as microemulsions, nanosuspensions, nanoparticles, liposomes,
niosomes, dendrimers, implants, and hydrogels. Potential for ocular gene therapy has also been described in this article.
In near future, a great deal of attention will be paid to develop non-invasive sustained drug release for both anterior and
posterior segment eye disorders. A better understanding of nature of ocular diseases, barriers and factors affecting in vivo performance, would greatly drive the development of new delivery systems. Current momentum in the invention of new drug delivery
systems hold a promise towards much improved therapies for the treatment of vision threatening disorders.
All the authors contributed equally to this work. |
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Keywords: | nanotechnology ocular drug delivery transporter |
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