妊高征患者血浆AM、CGRP的变化及临床意义

目的:探讨肾上腺髓质素(AM)、降钙素基因相关肽(CGRP)在妊高征发病中的作用及其临床意义。方法:采用放射免疫法测定55例妊高征患者及30例正常妊娠妇女血浆AM、CGRP浓度。结果:①妊高征患者血浆AM显著高于正常妊娠组(P<0.01),CGRP浓度则明显下降(P<0.05),妊高征各组间比较差异具有显著性(P<0.05);②妊高征患者血浆AM与平均动脉压(MAP)呈显著正相关(r=0.76,P<0.01),CGRP与MAP则呈负相关(r=-0.54,P<0.05);③妊高征患者血浆AM浓度与CGRP浓度呈负相关(r=-0.65,P<0.05)。结论:AM、CGRP共同参与妊高征的病理生理过程,联合检测其血浆浓度可以作为监测PIH病情的重要指标。

Changes in plasma AM and CGRP of patients with pregnancy-induced hypertension and its clinical significance

Objective:To assess the roles of plasma AM and CGRP levels in pathogenesis of pregnancy-induced hypertension(PIH) and its clinical value.Methods:Plasma AM and CGRP levels were mesured by radioimmunoassay in 55 patients with PIH and 30 normal pregnant women.Results:①The levels of AM in PIH were significantly higher than that in controls (P<0.01),but CGRP decreased obviously (P<0.05).②There were notable positive correlation between plasma AM levels and mean arterial pressure(MAP) in PIH(r=0.76,P<0.01),however,there was a negative correlation between plasma CGRP and MAP(r=-0.54,P<0.05).③A significant negative correlation between AM and CGRP(r=0.65,P<0.05).Conclusion:AM and CGRP could play an important role in pathophysiological process of PIH.Associated detection of plasma concentration may be used as indicators for the severity of PIH.