Prevalence of comorbidities in atopic dermatitis and psoriasis in the French population |
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| Authors: | M.-A. Richard J.-F. Sei C. Philippe C. Taieb P. Joly K. Ezzedine |
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| Affiliation: | 1. CEReSS-EA 3279, Dermatology Department, Research Centrer in Health Services and Quality of Life Aix-Marseille University, La Timone University Hospital, Assistance publique–Hôpitaux de Marseille (AP–HM), 13385 Marseille, France;2. Department of Dermatology, La Timone University Hospital, Marseille, France;3. Société française de dermatologie (SFD), Paris, France;4. Collège des enseignants de dermatologie de France (CEDEF), Paris, France;5. Fédération française de formation continue et d’évaluation en dermatologie – vénérologie (FFFCEDV), Paris, France;6. Department of Dermatology, hôpital Ambroise-Paré, AP–HP, Paris, France;7. Qualees, Paris, France;8. Department of Dermatology, hôpital Charles-Nicolle, Rouen University Hospital, Rouen, France;9. Department of Dermatology, CHU Mondor University Hospital, Créteil, France;1. Service de dermatologie, centre hospitalier de Dunkerque, avenue Louis-Herbeaux, 59240 Dunkerque, France;2. Laboratoire d’immunologie, centre hospitalo-universitaire de Rouen, Rouen, France;1. Service de dermatologie, hospices civils de Lyon, centre hospitalier Lyon-Sud, 69495 Pierre-Bénite cedex, France;2. Hospices civils de Lyon, groupement hospitalier Est, centre régional de traitement de l’Hémophilie, 69500 Bron cedex, France;3. Pharmacovigilance, hospices civils de Lyon, centre hospitalier Lyon Sud, 69495 Pierre-Bénite cedex, France;4. Service de maladies infectieuses et tropicales, hospices civils de Lyon, hôpital de la Croix Rousse, 69004 Lyon, France;5. Biologie médicale, centre hospitalier de Rouen, hôpital Charles-Nicole, 76031 Rouen cedex, France;6. Service d’anatomopathologie, hospices civils de Lyon, centre hospitalier Lyon Sud, 69495 Pierre-Bénite cedex, France;1. Dermatology Department, Saint-Louis Hospital, Paris, France;2. Pathology Department, Saint-Louis Hospital, Paris, France;1. Dermatology department, Cochin hospital, Paris public hospitals, Paris, France;2. Pathology department, Cochin hospital, Paris public hospitals, Paris, France;3. Dermatology department, CISSS de Chaudière-Appalaches-Hôtel-Dieu de Lévis, Lévis, QC, Canada;4. Private medical practice, 4, rue Léon-Delhomme, 75015 Paris, France;1. Department of oral surgery, Pellegrin university hospital, Bordeaux, France;2. Paris Salpêtrière university hospital, AP–HP, Paris, France;3. Massilien facial center, Marseille, France |
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| Abstract: | BackgroundAtopic dermatitis (AD) and psoriasis (Pso) are highly prevalent chronic inflammatory skin diseases. They share similarities regarding severity and impact on quality of life but display differences regarding risk factors, comorbidities, and pathogenesis.ObjectiveThis study sought to assess the prevalence of AD and Pso among the French population, along with associated comorbidities, and to compare these data with those of the age- and gender-adjusted French population with neither AD nor Pso.MethodsThe survey was conducted by a polling institute between September 1 and November 30, 2016, with proportional quota sampling being applied to render the study population representative of the French population. In all, 20 012 individuals were selected from among 900,000 internet users aged ≥ 15 years.ResultsOverall, 20,012 adults (48.8% men; 51.2% women) completed a digital questionnaire. The prevalence of AD was 4.65% [95% confidence interval (CI) 4.36%–4.94%] and that of Pso was 4.42% [95% CI: 4.14%–4.71%]. More AD patients presented ≥ 1 comorbidity compared to subjects without AD (57.04% vs. 49.2%, P < 0.0001) and more Pso patients presented ≥ 1 comorbidity compared to subjects without Pso (60.68% vs. 49.05%, P < 0.0001). After adjustment for gender and age, hypertension and dyslipidemia, a greater prevalence of osteoarticular, respiratory and psychiatric diseases was noted in both AD and Pso patients, whereas increased prevalence of obesity was seen only in Pso patients. The prevalence of components of metabolic syndrome was higher among Pso than AD patients.ConclusionFurther studies are required to consolidate these findings, to better characterize the entire spectrum of AD and Pso comorbidities, and to better identify determinants and risk factors, along with targeted therapies. |
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| Keywords: | Atopic dermatitis Psoriasis Comorbidity |
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