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IL-17A/F enable cholangiocytes to restrict T cell-driven experimental cholangitis by upregulating PD-L1 expression
Authors:Stephanie Stein  Lara Henze  Tobias Poch  Antonella Carambia  Till Krech  Max Preti  Fenja Amrei Schuran  Maria Reich  Verena Keitel  Romina Fiorotto  Mario Strazzabosco  Lutz Fischer  Jun Li  Luisa Marie Müller  Jonas Wagner  Nicola Gagliani  Johannes Herkel  Dorothee Schwinge  Christoph Schramm
Affiliation:1. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;2. Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;3. Clinic for Gastroenterology, Hepatology and Infectious Diseases, Heinrich-Heine-University, Düsseldorf, Germany;4. Liver Center, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA;5. Department of Hepatobiliary Surgery and Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;6. Leibniz Institute for Experimental Virology, Heinrich Pette Institute, Hamburg, Germany;7. Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;8. Immunology and Allergy Unit, Department of Medicine Solna, Karolinska Institute and University Hospital, Stockholm, Sweden;9. Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;10. Martin Zeitz Center for Rare Diseases, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
Abstract:
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  • Keywords:Interleukin (IL)-17  Programmed cell death ligand 1 (PD-L1)  Biliary epithelial cell  Cholangitis  CD8
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