食管癌MGMT、survivin 蛋白的表达及其临床意义

  目的 研究食管癌MGMT、survivin蛋白的表达及其临床意义。方法 应用免疫组化（EnVision二步法）检测56例食管鳞状细胞癌、20例腺样结构食管癌和9例小细胞癌组织中MGMT、survivin蛋白的表达，并分析其与临床病理诸因素之间的关系。结果 小细胞癌与鳞状细胞癌及腺样结构食管癌的MGMT蛋白表达比较均有显著性差异（P〈0．01）；低分化鳞癌MGMT蛋白阳性表达率为45．45％，低于高、中分化鳞癌的阳性率（84．44％，P〈0．05）。食管鳞状细胞癌survivin阳性表达率明显高于腺样结构食管癌（P〈0．05）。结论 MGMT、survivin蛋白表达与食管癌的组织学类型有密切关系，可作为食管癌预后判断的参考指标。

Expression and Clinical Significance of MGMT and survivin in Esophageal Carcinoma

Objective 　To investigate the expression and clinical significance of MGMT and survivin in esophageal carcinoma. Methods 　Expression and their relationship with clinicopathological parameters of MGMT gene and survivin proteins was detected by immunohistochemical techniques ( EnVision) in 56 cases of esophageal squamous cell carcinoma ,20 cases of carcinoma with adenoid st ructure and 9 cases of small cell carcinoma. Results 　Significant difference was observed in the expression of MGMT between small cell carcinoma and esophageal squamous cell carcinoma 、esophageal carcinoma with adenoid st ructure ( P < 0. 01) ; The positive rate of Survivin expression in poor differentiated esophageal squamous cell carcinoma (45. 45 %) was lower than that in well and moderate differentiated esophageal squamous cellcarcinoma (84. 44 % , P < 0. 05) . The expression of survivin was significantly higher in esophageal squamous cell carcinoma than in esophageal carcinoma with adenoid st ructure ( P < 0. 05) . Conclusion 　The expression of MGMT and survivin was signicantly correlated with histological type of the esophageal carcinoma ,which may be used as important indexes to evaluate the prognosis of esophageal carcinoma.