| 趋化因子在树突状细胞肿瘤疫苗研究中的进展 |
| |
| 引用本文： | 江良县,毕铁男,周申康,谭广. 趋化因子在树突状细胞肿瘤疫苗研究中的进展[J]. 国际外科学杂志, 2010, 37(12). DOI: 10.3760/cma.j.issn.1673-4203.2010.12.017 |
| |
| 作者姓名： | 江良县 毕铁男 周申康 谭广 |
| |
| 作者单位： | 大连医科大学附属第一医院普外二科,大连,116011;大连医科大学附属第一医院普外二科,大连,116011;大连医科大学附属第一医院普外二科,大连,116011;大连医科大学附属第一医院普外二科,大连,116011 |
| |
| 摘 要： | 趋化因子是一类调节免疫细胞定向迁移的细胞因子,其与表达于细胞表面的趋化因子受体结合而发挥生物学功能.树突状细胞(DC)是重要的专职抗原递呈细胞,其主要的应用是制备成各种肿瘤疫苗,树突状细胞功能的行使与趋化因子及其受体介导的细胞迁移密切相关,趋化因子在树突状细胞游走与迁徙过程中始终发挥着调节、促进或抑制的作用,从而促使树突状细胞递呈抗原、激活初始T细胞,引起机体免疫反应,杀伤、消灭肿瘤细胞和炎性分子.
|
| 关 键 词： | 趋化因子 树突状细胞 肿瘤疫苗 |
Research progress of chemokines in dendritic cell tumor vaccines |
| |
| JIANG Liang-xian,BI Tie-nan,ZHOU Shen-kang,TAN Guang. Research progress of chemokines in dendritic cell tumor vaccines[J]. International Journal of Surgery, 2010, 37(12). DOI: 10.3760/cma.j.issn.1673-4203.2010.12.017 |
| |
| Authors: | JIANG Liang-xian BI Tie-nan ZHOU Shen-kang TAN Guang |
| |
| Abstract: | Chemokine can regulate the immuue cells migration, play the function by combining chemokine receptor. Dendritic cells(DC) are the most important professional antigen presenting cells, and their main application is prepared into a variety of cancer vaccine. Dendritic cells need to migrate while completing the functions, are related with chemokine and chemokine receptor. Chemokines always playe a regulating, promoting or inhibiting role in the processing of completing the functions and migration. So DC can present antigens, activate the initial T cells, cause immune response and kill the tumor cells and inflammatory molecules. |
| |
| Keywords: | Chemokine Dendritic cell Tumor vaccine |
| 本文献已被 万方数据 等数据库收录！ |
|
