Cycloartane triterpenoid saponins from water soluble of Passiflora edulis Sims and their antidepressant-like effects |
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Authors: | Cong Wang Feng-Qing Xu Jian-Hua Shang Huai Xiao Wei-Wei Fan Fa-Wu Dong Jiang-Miao Hu Jun Zhou |
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Institution: | 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;2. College of Pharmacy, Dali College, Dali 671003, China;3. Yunnan Institute of Medical Material, Kunming 650111, China;4. Graduate University of Chinese Academy of Sciences, Beijing 100049, China |
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Abstract: | Ethnopharmacological relevanceVarious species of genus Passiflora have been used as traditional folk medicines owing to their sedative and anti-hypertensive properties. Passiflora edulis Sims most widely grown in the warm temperate for their fragrant fruits and their twigs and leaves are used as a folk medicine for treating both anxiety and nervousness in American countries. The present study was to evaluate the antidepressant-like effect and the active components of this plant.Materials and methodsThe alcohol extracts of the stems (PES, 10 and 2 g/kg of the plant materials) and leaves (PEL, 10 and 2 g/kg of the plant materials) of Passiflora edulis Sims were orally administered to mice for 7 day. The animals were tested in the forced swim test (FST) and tail suspension test (TST). After behavioral assay of ethanol extract, phytochemical research of the stems and leaves (5.7 kg) of Passiflora edulis Sims were developed and further bioactive verification of monomeric compounds were conducted.ResultsThere are mainly cycloartane triterpenoids and their saponins isolated from this plant, including two new cycloartane triterpenoid saponins named cyclopassifloside ХII (1) and ХIII (2), together with six known cycloartane triterpenoids, cyclopassifloic acids B and E, cyclopassiflosides II, VI, IX and XI. The ethanol extract of Passiflora edulis Sims together with isolated compounds cyclopassiflosides IX and XI may possess antidepressant-like effect.ConclusionsCycloartane triterpenoid was one of the main compositions of Passiflora edulis Sims and possess antidepressant-like activity. |
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Keywords: | Passiflora edulis Sims Cyclopassifloside Antidepressant-like effect |
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