Effect of diclofenac and glycol intercalation on structural assembly of phospholipid lamellar vesicles |
| |
| Authors: | Ines Castangia,Maria Letizia Manca,Pietro Matricardi,Chiara Sinico,Sandrina Lampis,Xavier Fernà ndez-Busquets,Anna Maria Fadda,Maria Manconi |
| |
| Affiliation: | 1. Dept. Scienze della Vita e dell’Ambiente, Sez. Scienze del Farmaco, CNBS, University of Cagliari, Cagliari, Italy;2. Dept. Chimica e Tecnologie del Farmaco, Sapienza, Università di Roma, Roma, Italy;3. Dept. Scienze Chimiche e Geologiche, CNBS and CSGI, University of Cagliari, Monserrato, CA, Italy;4. Barcelona Centre for International Health Research (CRESIB, Hospital Clínic-Universitat de Barcelona), Barcelona, Spain;5. Institute for Bioengineering of Catalonia (IBEC), Barcelona, Spain |
| |
| Abstract: | The aim of the current study was to improve the knowledge of drug–glycol–phospholipid-interactions and their effects in lamellar vesicle suitability as drug delivery systems. Liposomes were prepared using hydrogenated soy phosphatidylcholine (P90H, 60 mg/ml) and diclofenac sodium salt at two concentrations (5–10 mg/ml). To obtain innovative vesicles two permeation enhancers with glycol group, diethyleneglycol monoethyl ether and propylene glycol, were added to the water phase at different ratios (5%, 10%, and 20%). |
| |
| Keywords: | Phospholipid vesicles Glycols Cryo-TEM DSC SAXS Rheology |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
