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Genome-wide gene copy number and expression analysis of primary gastric tumors and gastric cancer cell lines |
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| Authors: | Siina Junnila Arto Kokkola Marja-Liisa Karjalainen-Lindsberg Pauli Puolakkainen Outi Monni |
| Affiliation: | (1) Medical Biochemistry and Developmental Biology, Genome-Scale Biology Research Program, Institute of Biomedicine, University of Helsinki, Helsinki, Finland;(2) Department of Surgery, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland;(3) Department of Pathology, Haartman Institute and HUSLAB, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland;(4) Department of Surgery, Turku University Hospital, Turku, Finland |
| Abstract: | BackgroundGastric cancer is one of the most common malignancies worldwide and the second most common cause of cancer related death. Gene copy number alterations play an important role in the development of gastric cancer and a change in gene copy number is one of the main mechanisms for a cancer cell to control the expression of potential oncogenes and tumor suppressor genes. |
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