香菇多糖对大鼠免疫调节作用的研究

目的]为证明香菇多糖等对大鼠免疫调节及T细胞亚群增殖的提升作用。方法]通过建立免疫缺陷模型,经复方活性多糖干预,采用流式细胞术观察T细胞亚群等变化。结果]常量组对淋巴细胞、CD3＋、CD4＋的增殖有明显的促进作用,脾指数、胸腺指数明显增加。促进LYM增殖的起始时间于干预1周后即可产生。结论]香菇多糖等具有增强细胞免疫调节功能,显著地促进CD4＋增殖和提高CD4＋/CD8＋,常量组和5倍剂量组有效、快速、可行。

STUDY ON THE EFFECT OF COMPOUND AMYLOSE ON IMMUNOREGULATION OF SD RATS

Objective]To prove the positive effect of compound amylose on the immunoregulation and T lymphocyte subsets of rats.Methods]The change of the T lymphocyte subsets and so on were observed through flow cytometer by building an immunodeficiency model with compound amylose intervention.Results]The intervene group had obvious positive effect on the proliferation of lymphocyte,CD3 ,and CD4 . The spleen index and thymus index increased obviously. The beginning time of lymphocyte proliferation occurred in one week after intervention.Conclusion]Compound amylose can regulate the function of cellular immunity,and remarkably prompt CD4 proliferation and increase the level of CD4 /CD8 . It is feasible,fast and effective in the group of normal dose.