多聚唾液酸神经细胞黏附分子在垂体腺瘤中的表达及其临床意义

目的 探讨垂体腺瘤中多聚唾液酸神经细胞黏附分子(PSA-NCAM)的表达及与侵袭性、组织学类型、Ki-67抗原之间的关系.方法 收集61例手术切除的垂体腺瘤标本及临床资料,3例正常垂体腺组织来自24 h内死亡的尸解标本,应用免疫组织化学法检测PSA-NCAM在不同类型腺瘤中的表达.结果 本组61例垂体瘤中有26例(52.6%)PSA-NcAM阳性表达,3例正常垂体组织皆为阴性.25例男性患者中11例(44.0%)PSA-NCAM阳性表达,36例女性患者中15例(41.7%)PSA-NCAM阳性表达,两者差异无统计学意义(P>0.05).PSA-NCAM阳性表达组的平均年龄(42.1±11.2)岁,阴性表达组为(44.7±12.4)岁,两者差异无统计学意义(P>0.05).PSA-NCAM阳性表达组的平均Ki-67抗原标记指数(Ki-67 LI)为(3.6±1.3)%,阴性表达组为(2.7±1.4)%,两者差异有统计学意义(P<0.05).PSA-NCAM阳性表达组的肿瘤平均宽度为(2.5±0.9)cm,阴性表达组的为(1.6±1.2)cm,差异有统计学意义(P<0.05).侵袭性垂体腺瘤的PSA-NCAM阳性表达率62.5%(20/32),非侵袭组20.7%(6/29),两者差异有统计学意义(P<0.01).结论 PSA-NCAM的表达与垂体腺瘤的大小、侵袭性、增殖指数密切相关,而与患者的性别、年龄等无明显相关.

The expression of PSA-NCAM in pituitary adenomas and its clinical implication

Objective To investigate the expression of polysialylated neural cell adhesion molecule(PSA-NCAM) and its relation with invasion, histology type and Ki-67 antigen. Methods Sixty specimens and clinical data of pituitary adenomas were collected after operation, and 3 cadaveric specimens of normal pituitary tissues were obtained. The expression of PSA-NCAM was detected by immunohistochem-isty. Results The positive expression rate of PSA-NCAM was 52. 6% in all pituitary adenomas, but no expression was detected in normal pituitary tissues. Of 25 male and 36 female patients with pituitary adenoma, the positive expression rate of PSA-NCAM was 44.0% and 41.7% respectively (P>0.05). The mean age was 42. 1 ± 11. 2 in PSA-NCAM expression group, and that was 44. 7 ± 12. 4 in PSA-NCAM no expression group (P>0.05 ). The Ki-67 label index ( Ki-67LI) was(3. 6±1. 3 ) % in PSA-NCAM expression group, and that was (2.7±1.4) % in PSA-NCAM no expression group (P <0. 05). The average tumor width was (2. 5±0. 9) cm in PSA-NCAM expression group, and that was (1.6±1.2) cm in PSA-NCAM no expression group (P<0.05). The positive expression rate of PSA-NCAM was 62. 5% in invasive pituitary adenomas, and that was 20. 7% in no invasive pituitary adenomas (P<0.01). Conclusion The PSA-NCAM expression of pituitary adenomas was related to its size, invasion, and proliferation index, but not to gender and age of the patients.