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| 雷公藤叶化学成分研究 | |
| 引用本文： | 曹煦,李创军,杨敬芝,魏佰兴,罗永明,张东明. 雷公藤叶化学成分研究[J]. 中国中药杂志, 2011, 36(8): 1028-1031 |
| 作者姓名： | 曹煦 李创军 杨敬芝 魏佰兴 罗永明 张东明 |
| 作者单位： | 1. 中国医学科学院,北京协和医学院,药物研究所,中草药物质基础与资源利用,教育部重点实验室,北京,100050;江西中医学院,江西,南昌,330004 2. 中国医学科学院,北京协和医学院,药物研究所,中草药物质基础与资源利用,教育部重点实验室,北京,100050 3. 福建汉堂生物制药股份有限公司,福建,泰宁,354400 4. 江西中医学院,江西,南昌,330004 |
| 基金项目： | 国家科技支撑计划项目(2009BA173B03);福建省科技重大专项(2009YZ0001-1-6) |
| 摘 要： | 目的:对雷公藤叶水提取物进行化学成分研究.方法:利用各种色谱方法进行化学成分分离,根据理化性质和波谱数据鉴定化合物的结构.结果:分离得到9个化合物,分别鉴定为(+)-lyoniresinol(1),(+)-isolarieiresinol(2),burselignan(3),dibutyl phthalate(4),cyclo-(S-Pro-R-Phe)(5),cyclo-(S-Pro-R-Leu)(6),cyclo-(S-Pro-S-Ile)(7),3-hydroxy-1-(4-hydroxy-3.5-dimethoxyphenyl)-1-propanone(8),胡萝卜苷(9).结论:1-3为4-苯基四氢萘类木脂素,5-7为二酮哌嗪类化合物(环二肽),化合物1-3,5-8为首次从该植物中分离得到. |
| 关 键 词： | 雷公藤叶 化学成分 木脂素 环二肽 |
| 收稿时间： | 2010-10-03 |
Study on chemical constituents from leaves of Tripterygium wilfordii |
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| CAO Xu,LI Chuangjun,YANG Jingzhi,WEI Baixing,LUO Yongming and ZHANG Dongming. Study on chemical constituents from leaves of Tripterygium wilfordii[J]. China Journal of Chinese Materia Medica, 2011, 36(8): 1028-1031 | |
| Authors: | CAO Xu LI Chuangjun YANG Jingzhi WEI Baixing LUO Yongming ZHANG Dongming |
| Affiliation: | Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herb Medicine, Ministry of Education, Institute of Materia Medica, Peking Union Medical College Chinese Academy of Medical Sciences, Beijing 100050, China;JiangXi University of Traditional Chinese Medicine, Nanchang 330004, China;Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herb Medicine, Ministry of Education, Institute of Materia Medica, Peking Union Medical College Chinese Academy of Medical Sciences, Beijing 100050, China;Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herb Medicine, Ministry of Education, Institute of Materia Medica, Peking Union Medical College Chinese Academy of Medical Sciences, Beijing 100050, China;Fujian Hantang Bio-Pharmaceutical Inc., Taining 354400;JiangXi University of Traditional Chinese Medicine, Nanchang 330004, China;Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herb Medicine, Ministry of Education, Institute of Materia Medica, Peking Union Medical College Chinese Academy of Medical Sciences, Beijing 100050, China |
| Abstract: | In order to study the chemical constituents of the leaves of Tripterygium wilfordii and provide references for the bioactive study,we isolated nine compounds from the dried leaves of Tripterygium wilfordii.Their structures were determined by application of spectroscopic(NMR,MS) and chemical methods.These compounds were isolated and identified as(+)-lyoniresinol(1),(+)-isolariciresinol(2),burselignan(3),dibutyl phthalate(4),cyclo-(S-Pro-R-Phe)(5),cyclo-(S-Pro-R-Leu)(6),cyclo-(S-Pro-S-Ile)(7),3-hydroxy-1-(4-h... |
| Keywords: | leaves of Tripterygium wilfordii chemical constituents lignan cyclic dipeptides |
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