Frequency of HLA-B27 subtypes in a Danish population and in Danish patients with ankylosing spondylitis |
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| Authors: | J. Baech S. Schmidt-Qlsen R. Steffensen K. Varming N. Grunne C. Jersild |
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| Affiliation: | Regional Centre for Blood Transfusion and Clinical Immunology;Department of Rheumatology, Aalborg Hospital, Denmark;Department of Clinical Immunology, Artius University Hospital, Skejby, Denmark |
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| Abstract: | ![]()
Polymerase chain reaction in combination with sequence-specific oligonucleotide probes were used to analyze nine HLA-B27 subtypes among 51 healthy I HLA-B27 positive Danish blood donors and 30 Danish HLA-B27 positive patients with ankylosing spondylitis (AS). In the group of healthy Danes we found two subtypes, B*2705 (90.2%) and B*2702 (9.8%), however, among the AS patients only the B*2705 subtype was detected. We did not find a significant evidence for associations between AS and a particular HLA-B27 subtype in a Danish population. |
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| Keywords: | ankylosing spondylitis HLA-B27 subtype PCR-SSO population stufiy |
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