Interaction between ESRα polymorphisms and environmental factors in osteoporosis |
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| Authors: | Tomoko Sonoda Junichi Takada Kousuke Iba Sumiyo Asakura Toshihiko Yamashita Mitsuru Mori |
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| Affiliation: | 1. Department of Public Health, Sapporo Medical University School of Medicine, 1‐17, Chuo‐ku, Sapporo, Hokkaido 060‐8556, Japan;2. Department of Orthopaedic Surgery, Sapporo Medical University School of Medicine, Sapporo, Japan |
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| Abstract: | We hypothesized that environmental factors might affect the relationship between genetic predisposition and the risk of bone mineral density (BMD) loss. Cases were 114 Japanese women with a confirmed diagnosis of postmenopausal osteoporosis and controls were 171 general Japanese women. Genetic risk of SNPs in the estrogen receptors was analyzed by a case–control study. The interaction between gene and environmental factors for osteoporosis were assessed by a case‐only design. Significant increases in osteoporosis risk were observed with minor alleles of rs2077647 located in the first exon and rs2234693 located in the first intron of estrogen receptor α (ESRα). Haplotype CC at these risk SNPs was strongly associated with osteoporosis risk (odds ratio [OR] = 3.15, 95% confidence interval [CI] = 1.83–5.41). There was a statistically significant interaction between haplotype CC and alcohol drinking; moderate alcohol consumption decreased genetic risk of osteoporosis (OR = 0.22, 95%CI = 0.05–0.83). © 2012 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 30:1529–1534, 2012 |
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| Keywords: | osteoporosis ESRα interaction alcohol drinking Japanese |
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