声诺维对猪左右心室的影响

目的 评估超声造影剂声诺维对猪心室内径及收缩功能的影响.方法 16头小型猪随机分为实验组和对照组.实验组经耳静脉持续缓慢注射1 ml声诺维,20 min后重复;对照组注射同等剂量的生理盐水.测量基础状态、注射声诺维后左右心室收缩末内径、舒张末内径、短轴缩短率,及注射声诺维后左右室内径变化的最大值以及达到最大值的时间、恢复到基线值的时间.结果 两组基础参数差异无统计学意义.实验组初次注射声诺维后,右室舒张末内径(RVEDD)由基线(25.88±1.38)mm增加至最大值(33.26±0.99)mm,左室舒张末期内径(LVEDD)由基线(38.10±1.39)mm减小至最小值(26.25±0.65)mm;而右室短轴缩短率(RVFS)由基线(26.90±1.92)%升高至最大值(33.92±2.53)%,左室短轴缩短率(LVFS)由基线(36.24±1.93)%下降至最小值(29.13±3.00)%,与基础值相比差异均有统计学意义(P<0.05);平均(10.15±0.59)min达变化最大值,(9.00±0.56)min恢复到基线值.对照组注射生理盐水后参数无变化.重复注射声诺维后,再次出现右室扩张RVEDD最大值(29.98±1.23)mm]、左室受压LVEDD最大值(31.91±1.64)mm],RVFS最高为(31.09±1.90)%,LVFS最低为(32.17±2.31)%,变化幅度均小于第1次(P<0.05),而达变化最大值的时间(8.73±0.55)min]及恢复到基础值的时间(6.89 ±0.43)min]均短于第1次(P<0.05).结论 静脉注射声诺维导致一过性右室扩张,收缩功能增强,左室受压和收缩功能下降.重复使用后,左右室所受的影响小于第1次.

Effect of SonoVue on left and right ventricle in pigs

Objective To assess the effect of ultrasound contrast agent SonoVue on the dimensions and systolic function of left and right ventricle in pigs. Methods Sixteen pigs were randomly assigned to two groups. Intravenous injection of 1 ml of SonoVue were given in study group, and repeated 20 min later. The control group was given the same doses of saline. Before and after the administration of contrast agent, the end-diastolic dimension (LVEDD, RVEDD). end-systolic dimension ( LVESD, RVESD) and fractional shortening(LVFS,RVFS) of left and right ventricle were measured. The time to reach the extreme value of these parameters and the time to return to the baseline were recorded. Results There was no significant difference regarding the parameters at baseline between the two groups. After injection of SonoVue,RVEDD significantly increased from (25. 88 ± 1. 38) mm at baseline to its maximum of (33. 26 ± 0. 99)mm( P < 0. 05). Accordingly,RVFS significantly increased from (26. 90 ± 1. 92) % to (33. 92 ± 2. 53) % ( P <0. 05). Meanwhile,LVEDD remarkably decreased from (38.10 ± 1. 39)mm at baseline to its minimum of (26.25 ± 0. 65)mm( P <0. 05) and LVFS remarkably decreased from (36. 24 ± 1. 93) % to (29.13 ± 3.00) % ( P < 0. 05). There was no change in the control group after administration of the saline. When SonoVue was given repeatedly, the maximum RVEDD and RVFS was (29. 98 ± 1. 23) mm and (31. 09 + 1.90) % , respectively, which had less increase compared to the first time. Minimum LVEDD and LVFS was (31. 91 ± 1, 64)mm and (32. 17 ± 2. 31)%,respectively,with less decrease compared with which at first injection. It took (10. 15±0. 59) min for the right and left ventricle to reach the extreme value and (9.00± 0. 56) min to return to the baseline at the first injection. The time used for the right and left ventricle to reach its peak change and back to baseline after second injection of SonoVue were shorter (8.73± 0.55) min and (6.89± 0.43) min, respectively,both P <0.05]. Conclusions Administration of SonoVue was associated with acute, transient dilation of right ventricle and compression of left ventricle. The influence of SonoVue on the right and left ventricle became less at it second injection.