| 槲皮素对K562细胞生长及血管内皮生长因子分泌的影响 |
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| 引用本文： | 钟璐,陈芳源,王海嵘,王晨,欧阳仁荣. 槲皮素对K562细胞生长及血管内皮生长因子分泌的影响[J]. 白血病．淋巴瘤, 2006, 15(3): 161-163 |
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| 作者姓名： | 钟璐 陈芳源 王海嵘 王晨 欧阳仁荣 |
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| 作者单位： | 200001,上海第二医科大学附属仁济医院血液科;200001,上海第二医科大学附属仁济医院血液科;200001,上海第二医科大学附属仁济医院血液科;200001,上海第二医科大学附属仁济医院血液科;200001,上海第二医科大学附属仁济医院血液科 |
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| 摘 要： | 目的 探讨槲皮素对K562细胞的形态、血管内皮生长因子（VEGF）的表达影响。方法 以K562细胞为研究对象，细胞形态学观察采用Wright染色法；AnnecxinⅤ标记检测细胞凋亡率；VEGF表达采用ELISA法。结果 经槲皮素处理后，细胞形态学上出现凋亡特征性改变；槲皮素处理后K562细胞凋亡率明显增加；槲皮素处理后K562细胞显著降低VEGF的表达。结论 槲皮素在体外能抑制白血病细胞K562生长并诱导其凋亡；槲皮素可抑制白血病细胞分泌VEGF。
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| 关 键 词： | 槲皮素 K562细胞生长 血管内皮生长因子 |
| 文章编号： | 1009-9921（2006）03-0161-03 |
| 收稿时间： | 2005-06-27 |
| 修稿时间： | 2006-01-25 |
Effects of quercetin on cell morphology and expression of VEGF in K562 cell |
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| ZHONG Lu,CHEN Fang-yuan,WANG Hai-rong,WANG Cheng,OUYANG Ren-rong. Effects of quercetin on cell morphology and expression of VEGF in K562 cell[J]. Journal of Leukemia & Lymphoma, 2006, 15(3): 161-163 |
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| Authors: | ZHONG Lu CHEN Fang-yuan WANG Hai-rong WANG Cheng OUYANG Ren-rong |
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| Affiliation: | Department of Hematology, Renji Hospital, the Second Medical University, Shanghai 200001, China |
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| Abstract: | Objective To investigate the effects of quercetin on cell morphology, expression of VEGF of K562 cell. Methods Cells morphology assayed by Wright's stain, apoptosis rate by apoptotic marker An－necxin Ⅴ and VEGF expression by ELISA. Results The typical apoptosis was found in K562 cell after treatment with quercetin. Apoptotic marker Annecxin Ⅴanalysis showed after treatment with quercetin, the apoptotic rate was increased in K562 cell. The expression of VEGF in K562 cell was significantly decreased after treatment with quercetin. Conclusion Quercetin can inhibit the proliferation and induce K562 cell apoptosis. It also can inhibit the expression of VEGF in leukemia cell. |
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| Keywords: | Quercetin VEGF K562 cell |
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