肝细胞癌病人血浆TF,uPA及uPAR检测的临床意义

目的 探讨肝细胞癌病人血浆TF,uPA和uPAR水平变化及临床病理意义。方法应用酶联免疫法(ELISA)检测肝细胞癌病人50例及对照组30例的血浆TF,uPA和uPAR水平,并结合临床病理资料探讨其临床意义。结果 肝细胞癌病人血浆TF,uPA及uPAR均较对照组升高,差异有显著性(P<0.05)。肝细胞癌病人血浆TF在低分化组,肿瘤较大组及合并肝硬化组显著升高(P<0.05),而在不同癌灶数目及包膜情况组间无显著差异(P>0.05)。血浆uPA水平只在合并肝硬化组升高(P<0.05),uPAR水平与以上病理指标均无关(P>0.05)。肝细胞癌病人血浆TF,uPA和uPAR水平均与侵袭转移指标有关,在有淋巴转移,肝外脏器转移及门脉癌栓组较无转移及癌栓组升高(P<0.05)。结论 肝细胞癌病人存在凝血,纤溶激活状态。血浆 TF,uPA和uPAR升高与肝细胞癌的发生及侵袭转移有关,其检测有助于早期诊断病情及判断预后。

Clinical significance of detecting plasma TF,uPA and uPAR levels in hepatocellular carcinoma

jective To study the levels change of plasma TF, uPA and uPAR levels and their clinical significance in Hepatocellular Carcinoma(HCC). Methods Blood samples were obtained from 50 patients of HCC and 30 cases of control. Plasma levels of TF, uPA and uPAR of all samples were detected by ELISA. The relationships between the three factors and clinic-pathological data were analyzed by SPSS software. Results Plasma TF, uPA and uPAR levels were all increased significantly in HCC group when compared with control (P<0. 05). TF levels were higher in poor differentiation, large size and cirrhosis subgroup in HCC patients (P<0. 05) but similar in different tumor number or envelope. uPA levels were not significantly different in different differentiation, tumor size, mass numbers, and envelope. uPA in HCC with cirrhosis subgroup were higher than no cirrhosis one. uPAR levels were not significantly different in all above subgroup. Plasma TF, uPA and uPAR levels were all related with the invasive and metastatic factor, they were all significantly increased in extrahe-patic metastasis, lymphatic metastasis and portal venous tumor thrombus subgroups (P<0. 05). Conclusions Coagulation and anticoagulation were activated in HCC. The increasing TF, uPA and uPAR levels in plasma might be related with the carcinogenesis and metastasis in HCC and might be useful clinical markers for early diagnosis and prognosis.