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| p16、CyclinD1及nm23在非小细胞肺癌中的表达 | |
| 引用本文： | 付静,史春祥,李小钢,张骏.p16、CyclinD1及nm23在非小细胞肺癌中的表达[J].诊断病理学杂志,2000,7(1):36-38,I013. |
| 作者姓名： | 付静 史春祥 李小钢 张骏 |
| 作者单位： | 1. 北京市海淀医院,病理科,100080 2. 北京市海淀医院,胸外科,100080 3. 北京医科大学病理系 |
| 摘 要： | 目的 研究非小细胞肺癌（ＮＳＣＬＣ）组织中ｐ１６、Ｃｙｃｌｉｎ Ｄ１及ｎｍ２３基因蛋白的表达和意义。方法 应用免疫组化ＳＰ方法检测６４例ＮＳＣＬＣ中ｐ１６、Ｃｙｃｌｉｎ Ｄ１及ｎｍ２３蛋白的表达。结果 ｐ１６、Ｃｙｃｌｉｎ Ｄ１及ｎｍ２３在ＮＳＣＬＣ中的表达率分别为４２．２％、６５．６％、５３．１％；ｐ１６蛋白阳性表达率与ＮＳＣＬＣ的分化程度和患者术后生存期呈正相关（Ｐ〈０．０５）；ｐ１６、ｎｍ２ |
| 关 键 词： | 非小细胞肺癌 p16基因 Cyclin D1基因 nm23基因 |
| 文章编号： | 1007-8096(2000)01-0036-03 |
| 修稿时间： | 1999-11-02 |
Significance of p16, Cyclin D1 and nm23 protein expression in Non-small cell lung cancer |
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| Fu jing ,Shi Chunxiang ,Li Xiaogang.Significance of p16, Cyclin D1 and nm23 protein expression in Non-small cell lung cancer[J].Chinese Journal of Diagnostic Pathology,2000,7(1):36-38,I013. | |
| Authors: | Fu jing Shi Chunxiang Li Xiaogang |
| Institution: | Fu jing ,Shi Chunxiang ,Li Xiaogang (Department of Pathology, Haidian hospital, Beijing 100080) |
| Abstract: | Objective To study the significance of p16, Cyclin D1 and nm23 gene protein expression in non-small cell lung cancer(NSCLC). Methods Expression of p16,Cyclin D1 and nm23 protein in 64 cases of NSCLC were detected using im-munohistochemical S-P method. Results The positive rates of p16, cyclin D1 and nm23 protein in NSCLC were 42.2%,65.6% and 53.1% respectively; The expression were not correlated with histological type,but the expression of p16 protein was related to the degree of differentiation,lymph node metastasis and prognosis (P<0.05);the expression of nm23 protein was re-lated to lymph node metastasis (P<0.05);prognosis of the patients was poor as the three proteins were all aberranty expressed.Conclusion Aberrant expression of the three gene proteins may be taken an effective parameter to evaluate and predict the prog-nosis of NSCLC. |
| Keywords: | NSCLC p16 gene protein Cyclin D1 gene protein nm23 gene protein prognosis |
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