| 知母宁在神经退行性疾病中作用机制的研究进展 |
| |
| 引用本文： | 冯思同,张毅.知母宁在神经退行性疾病中作用机制的研究进展[J].中草药,2020,51(2):542-548. |
| |
| 作者姓名： | 冯思同 张毅 |
| |
| 作者单位： | 北京中医药大学中医学院解剖学教研室, 北京 102488,北京中医药大学中医学院解剖学教研室, 北京 102488 |
| |
| 基金项目： | 国家自然科学基金资助项目（81473376）；北京中医药大学科研纵向发展基金项目（2019-ZXFZJJ-074） |
| |
| 摘 要： | 知母宁是一种具有C-糖苷和氧杂蒽酮成分的天然化合物,具有抗氧化、抗炎性损伤、提高线粒体生物能量和改善认知缺陷等多种生物活性,可以通过血脑屏障在中枢神经系统中发挥神经保护作用。对知母宁在神经退行性疾病中的作用及机制研究进展进行综述,以此探究其发挥神经保护作用的潜在分子机制,为其进一步的研究和应用提供参考。
|
| 关 键 词： | 知母宁 神经退行性疾病 神经保护作用 阿尔茨海默病 帕金森病 |
| 收稿时间： | 2019/9/10 0:00:00 |
Research progress on mechanism of chinonin in treatment of neurodegenerative diseases |
| |
| FENG Si-tong and ZHANG Yi.Research progress on mechanism of chinonin in treatment of neurodegenerative diseases[J].Chinese Traditional and Herbal Drugs,2020,51(2):542-548. |
| |
| Authors: | FENG Si-tong and ZHANG Yi |
| |
| Institution: | Department of Anatomy, School of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 102488, China and Department of Anatomy, School of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 102488, China |
| |
| Abstract: | Chinonin is a natural compound with C-glycoside and xanthones, possessing several biological effects, such as anti-oxidation, anti-inflammation, improving mitochondrial bioenergy and ameliorating cognitive deficits. Moreover, chinonin can exert its neuroprotective effect on the central nervous system through the blood-brain barrier. This review discusses the pathophysiological mechanisms of Alzheimer''s disease and Parkinson''s disease in neurodegenerative diseases, for the purpose of investigating the underlying mechanisms of chinonin in neuroprotection and providing the reference for its further research and application. |
| |
| Keywords: | chinonin neurodegenerative diseases neuroprotection Alzheimer''s disease Parkinson''s disease |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《中草药》浏览原始摘要信息 |
| 点击此处可从《中草药》下载免费的PDF全文 |
|
