儿童百日咳181例临床分析

目的 探讨儿童百日咳的临床特点.方法 回顾性分析江西省儿童医院2017年1月至2020年1月收治的181例百日咳患儿的临床资料.按年龄分为≤3个月组(n=88)、>3个月组(n=93);按有无接种百白破疫苗(DTP)分为免疫组(n=23)、未免疫组(n=137),排除未接种完全16例,接种史不详5例;按有无混合其他病原...

Clinical Analysis of 181 Children with Pertussis

Objective To investigate the clinical characteristics of pertussis in children.MethodsClinical data of 181 pertussis children admitted Jiangxi Children’s Hospital between January 2017 to January 2020 were retrospectively analyzed.According to the age,these children were divided into≤3 months old group(n=88)and>3 months old group(n=93).According to whether they had received diphtheria-tetanus-pertussis(DTP)vaccine,these children were divided into immunized group(n=23)and non-immunized group(n=137).Sixteen children with incomplete inoculation and 5 children with unknown inoculation history were excluded.According to whether they had mixed infection with other pathogens,these children were divided into non-mixed infection group(n=78)and mixed infection group(n=103).The clinical characteristics were compared between different groups.Results Compared with>3 months old group,the incidence of spasmodic cough,paroxysmal cyanosis,apnea,asphyxia,respiratory failure,severe pneumonia,pulmonary consolidation and/or atelectasis,red blood cell(WBC)count,and length of hospital stay increased in≤3 months old group(P<0.05).Compared with non-immunized group,the incidence of respiratory failure and severe pneumonia,WBC count,and length of hospital stay increased in immunized group(P<0.05).Paroxysmal cyanosis,apnea,respiratory failure,asphyxia and severe pneumonia were found only in non-immunized group.Compared with non-mixed infection group,the incidence of pulmonary consolidation and/or atelectasis,WBC count,and length of hospital stay increased in mixed infection group(P<0.05).Conclusion Children with pertussis who are≤3 months of age and have not received DTP vaccine are sicker and stay longer in hospital than children who are>3 months of age and have received DTP vaccine.Mixed infection with other pathogens is an important factor affecting the therapeutic efficacy for pertussis.In addition,WBC level can indicate the prognosis of pertussis children to some extent.