福辛普利钠联合骨化三醇治疗对老年IgA肾病患者肾功能及血清T淋巴细胞亚群水平的影响

目的 探讨福辛普利钠联合骨化三醇治疗对老年免疫球蛋白A肾病患者肾功能及血清T淋巴细胞亚群水平的影响.方法 将108例老年免疫球蛋白A肾病患者按照随机数字表法分为研究组与对照组,各54例.两组均给予福辛普利钠治疗,研究组联合骨化三醇治疗.比较两组临床疗效及不良反应发生率,比较治疗前后两组血肌酐、尿素氮、24 h尿蛋白定量...

The effect of fosinopril sodium combined with calcitriol in the treatment of elderly IgA nephropathy on renal function and serum T lymphocyte subgroup levels

Objective To investigate the effect of fosinopril sodium combined with calcitriol in the treatment of elderly IgA nephropathy on renal function and serum T lymphocyte subgroup levels.Methods A total of 108 elderly patients with IgA nephropathy were divided into study group(n=54)and routine group(n=54)according to random number table method.Both groups were treated with fosinopril sodium,and the study group was treated with calcitriol.The clinical efficacy and the incidence of adverse reactions were compared between the two groups.Serum creatinine(Scr),blood urea nitrogen(BUN),24-hour urinary protein quantity(TP/24 h),CD8⁺,CD4⁺,CD4⁺/CD8⁺levels were compared between the two groups before and after treatment.Results The total effective rate of treatment in the study group was significantly higher than that in the control group(P<0.05).After treatment,the levels of Scr and TP/24 h in the study group were significantly lower than before treatment(P<0.05 or 0.01),and were significantly lower than those in the control group(P<0.05 or 0.01),and the BUN level was significantly higher than before treatment(P<0.01),and significantly higher than the control group(P<0.05).The TP/24 h level of the control group was significantly lower than before treatment(P<0.01).After treatment,the CD4⁺and CD4⁺/CD8⁺levels in the study group were significantly lower than before treatment(P<0.01),the CD8⁺level in the control group was significantly higher than before treatment(P<0.01),and the CD4⁺level was significantly reduced(P<0.05),the CD8⁺,CD4⁺,CD4⁺/CD8⁺levels in the study group were significantly lower than the control group(P<0.05 or 0.01).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions Fosinopril sodium combined with calcitriol has a significant effect in the treatment of elderly patients with immunoglobulin A nephropathy,which can effectively improve the renal function and serum T lymphocyte subgroup levels in patients with high safety.