Mice that are congenic for the char2 locus are susceptible to malaria |
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| Authors: | Burt Rachel A Marshall Vikki M Wagglen Jamie Rodda Fleur R Senyschen Danielle Baldwin Tracey M Buckingham Lynn A Foote Simon J |
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| Affiliation: | The Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria 3050, Australia. |
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| Abstract: | ![]()
A major advance has been made towards the positional cloning of char2 (a quantitative trait locus encoding resistance to Plasmodium chabaudi malaria). Mice congenic for the locus have been used to fine map the gene and to prove that char2 plays a significant role in the outcome of malarial infection, independently of other resistance loci. |
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