3.0T磁共振扩散峰度成像参数与AFP的相关性及对原发性肝癌的诊断价值研究

目的 探究3.0T磁共振扩散峰度成像（diffusion kurtosis imaging，DKI）参数与甲胎蛋白(alpha fetroprotein，AFP)的相关性及对原发性肝癌的诊断价值。方法 回顾性选取2020年8月至2022年1月台州市中心医院（台州学院附属医院）收治的80例原发性肝癌患者作为观察组，并选取同期进行健康体检的80例健康者为对照组。同时，按照病情程度，将对照组的80例肝癌患者分为轻度组（n=23）、中度组（n=26）和重度组（n=21）。两组患者均进行3.0T磁共振观察患者的DKI参数，包括平均扩散率(mean diffusivity, MD)、各向异性(anisotropy, FA)、径向扩散系数(radial diffusion coefficient, Dr)、轴向扩散系数(axial diffusion coefficient, Da)，检测血清甲胎蛋白(α-fetoprotein，AFP)，观察3.0T磁共振DKI参数与AFP、病情严重程度的相关性。分析3.0T磁共振DKI参数对原发性肝癌的诊断价值。结果 与对照组相比，观察组FA较高，Da、MD、Dr、AFP较低，差异均有统计学意义（P<0.05）；与轻度组相比，重度组、中度组的FA参数较高，Da、MD、Dr较低，差异均有统计学意义（P<0.05），与疾病严重程度具有相关性（P<0.05），通过受试者操作特征（receiver operator characteristic，ROC）曲线分析发现联合检测对于原发性肝癌的诊断效能更高。结论 3.0T磁共振DKI参数与AFP具有相关性，对原发性肝癌具有较高的诊断价值，值得在临床应用。

correlation between 3.0T MR diffusion kurtosis imaging parameters and AFP and the diagnostic value of primary liver cancer

Objective To explore the correlation between 3.0T magnetic resonance diffusion (diffusion kurtosis imaging (DKI) parameters and alpha fetroprotein (AFP) and the diagnostic value of primary liver cancer. Methods From August 2020 to January 2022, 80 patients with primary liver cancer detected in Taizhou Central Hospital (Taizhou University Hospital) were retrospectively selected as the observation group for research, and 80 healthy people who underwent physical examination were selected as the control group. 80 patients with primary liver cancer in the control group were divided into mild group (n=23), the moderate group (n=26) and the severe group (n=21) according to their degree of disease. 3.0T magnetic resonance imaging was performed to observe the DKI parameters of patients in both groups, including mean diffusivity (MD), anisotropy (FA), radial diffusion coefficient (Dr), axial diffusion coefficient (Da), and serum AFP was detected, and observed the correlation between 3.0T magnetic resonance DKI parameters, AFP and disease severity, analyzed the diagnostic value of 3.0T magnetic resonance DKI parameters for primary liver cancer. Results Compared with the control group, the observation group had higher FA, lower Da, MD, Dr And AFP, with statistical differences (P<0.05). Compared to the mild group, the FA parameters were higher and Da, MD and Dr were lower in the severe and moderate groups, all with statistically significant differences (P<0.05), correlatied with disease severity (P<0.05). Receiver operator characteristic(ROC) curve showed that combined detection had higher diagnostic efficacy for primary liver cancer. Conclusion 3.0T MR DKI parameters are associated with AFP, which have high diagnostic value for primary liver cancer, and are worth promotion in clinical practice.