Effect of maternal selenium deficiency on the teratogenicity of methylmercury |
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| Authors: | N Nishikido Y Satoh A Naganuma N Imura |
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| Institution: | Department of Public Health, School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan. |
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| Abstract: | The teratogenicity of methylmercury was examined in selenium-deficient and selenium-sufficient mice of the ICR strain. A single oral dose of 75 mumol/kg of methylmercuric chloride (MMC) on day 10, 11 or 12 of gestation caused similar incidences of a cleft palate in the selenium-deficient and selenium-sufficient mice. The treatment on day 11 led to the highest incidence of a cleft palate in both groups. These results suggest that a maternal selenium deficiency has no effect on the incidence or on the critical gestational period for an MMC-induced cleft palate. |
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