Laboratory for Lymphocyte Differentiation, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan.
Abstract:
Download : Download high-res image (308KB)
Download : Download full-size image
Highlights? STIM proteins are required for BCR-mediated SOC influx and proliferation ? STIM proteins are dispensable for B cell development and antibody responses ? STIM-mediated NFAT activation induces IL-10 production by B cells ? STIM-dependent IL-10 production by B cells suppresses the development of autoimmunity
