帕瑞昔布钠治疗术后疼痛的跟踪研究

目的跟踪研究帕瑞昔布钠对于腹腔镜下胃肠切除术后镇痛的效果和安全性。方法选择择期腹腔镜下胃肠切除手术患者80例,ASA评分为Ⅰ～Ⅱ级,体重在50kg的青中老年患者。将其随机分为两组,每组40例。A组40例,静脉注射帕瑞昔布钠40mg/5ml0.9%NS。B组为对照组40例,静脉注射0.9%NaCl溶液5ml。如果患者术后不能耐受疼痛,单次肌内注射盐酸哌替啶50mg。记录各组患者术毕清醒拔管后10、40、80、120、160min后VAS评分。手术后160min哌替啶的用量和所追加的次数,并观察其恶心、呕吐等不良反应的发生率及术后160min患者对镇痛的满意程度。结果术后160min内AB两组VAS评分差异有统计学意义(p<0.05),且A组患者满意度较B组高,镇痛效果好,用药副反应少。结论应用帕瑞昔布钠40mg对腹腔镜下胃肠切除手术后镇痛有很好效果,且不增加副作用。

FOLLOW-UP STUDY OF PARECOXIB TREATING POSTOPERATIVE PAIN

Objective Follow-up study of the analgesic effect and safety of parecoxib.love after laparoscopic gastrointestinal resection.Methods Choose elective surgery patients undergoing laparoscopic gastrointestinal resection 80 cases,ASA score for Ⅰ ～ Ⅱ level,weight 50kg youth to elderly patients.It＇s randomly divided into two groups,40 cases in each group.Group A=40,intravenous parecoxib 40 mg/5 ml in 0.9% sodium NS.Group B（control group）=40,intravenous 0.9% 5ml NaCl solution.If the patient postoperative cannot tolerate pain,a single muscle injection of hydrochloride50 mg.Record each patient group＇s postoperative awaken extubation 10 min,40 min,80 min,120 min,and 160 min later VAS score.160 min after surgery Pethidine dosage and additional times,and observed the incidence of nausea and vomiting etc adverse reactions and patients＇ postoperative analgesia satisfaction 160 min after aurgery.Results Within postoperative 160 min VAS score of two groups has statistically significant difference（p0.05）,patient＇s satisfaction of group A is higher than group B and analgesic effect is better,medication side effects are less.Conclusion The application of parecoxib 40 mg to laparoscopic gastrointestinal surgery has very good result in postoperative analgesia,without increase of side effects.