Differential inotropic and chronotropic effects of various protein kinase C activators on isolated guinea pig atria |
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| Authors: | I Teutsch A Weible M Siess |
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| Affiliation: | 1. Guangxi University of Chinese Medicine, Nanning, Guangxi 530001, China;2. Department of Orthopedics, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning, Guangxi 530011, China;3. Institute of Orthopedics, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning, Guangxi 530011, China;4. Global Initiative to Cure Paralysis (GICUP Alliance), Columbus, OH 43221, United States;5. Department of Medicine School, Guangxi University, Nanning, Guangxi 530004, China;6. Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec H3A 0G4, Canada;7. Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario M5S 1A8, Canada;8. Department of Imaging, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning, Guangxi 530011, China;1. Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, IA, 52242, USA;2. Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USA;3. Department of Family Medicine, University of Iowa, Iowa City, IA, 52242, USA;4. Department of Laboratory Medicine, University of Washington, Seattle, WA, 98195, USA;5. LetsGetChecked Laboratories, Monrovia, CA, 91016, USA |
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| Abstract: | ![]()
1,2-Dioctanoylglycerol (10-100 microM) produced a positive inotropic effect on electrically stimulated left guinea pig atria and increased the frequency of spontaneously beating atria. Various phorbol esters and mezerein induced heterogeneous responses of the left atria. Phorbol dibutyrate and phorbol didecanoate decreased the force of contraction to different extents, whereas phorbol myristate acetate and mezerein had dual actions: an initial enhancement followed by a decline in force. None of these compounds changed the spontaneous atrial rate. |
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