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In vivo labeling of serotonin-containing neurons by 5,7-dihydroxytryptamine inAplysia
Authors:Behrus Jahan-Parwar   Katalin S.-Rozsa   Janos Salanki   Martyn L. Evans  David O. Carpenter
Affiliation:New York State Department of Health, Wadsworth Center for Laboratories and Research, University at Albany, NY 12201.
Abstract:
Intrahemocoelial administration of 5,7-dihydroxytryptamine (5,7-DHT) to Aplysia californica induces a transient (less than 4 h) behavioral alteration. About 5 weeks after 5,7-DHT treatment, 5-hydroxytryptamine (5-HT)-containing neurons develop dark brown pigmentation. These labeled 5-HT neurons have normal physiological and pharmacological properties when investigated electrophysiologically. This contrasts with the long-term neurotoxic effect of 5,7-DHT on vertebrate neurons. This technique will greatly facilitate visual identification of 5-HT-containing neurons and study of their physiology and actions.
Keywords:5-Hydroxytryptamine   5,7-Dihydroxytryptamine   In vivo labeling   5-Hydroxytryptamine neuron   Aplysia
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