In vivo labeling of serotonin-containing neurons by 5,7-dihydroxytryptamine inAplysia |
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Authors: | Behrus Jahan-Parwar Katalin S.-Rozsa Janos Salanki Martyn L. Evans David O. Carpenter |
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Affiliation: | New York State Department of Health, Wadsworth Center for Laboratories and Research, University at Albany, NY 12201. |
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Abstract: | Intrahemocoelial administration of 5,7-dihydroxytryptamine (5,7-DHT) to Aplysia californica induces a transient (less than 4 h) behavioral alteration. About 5 weeks after 5,7-DHT treatment, 5-hydroxytryptamine (5-HT)-containing neurons develop dark brown pigmentation. These labeled 5-HT neurons have normal physiological and pharmacological properties when investigated electrophysiologically. This contrasts with the long-term neurotoxic effect of 5,7-DHT on vertebrate neurons. This technique will greatly facilitate visual identification of 5-HT-containing neurons and study of their physiology and actions. |
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Keywords: | 5-Hydroxytryptamine 5,7-Dihydroxytryptamine In vivo labeling 5-Hydroxytryptamine neuron Aplysia |
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