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| 大鼠静脉注射羟喜树碱脂质体的胆汁排泄研究 | |
| 引用本文： | 周卫,平其能. 大鼠静脉注射羟喜树碱脂质体的胆汁排泄研究[J]. 中国药学杂志, 2008, 43(17): 1339-1341 |
| 作者姓名： | 周卫 平其能 |
| 作者单位： | 1.南京工业大学江苏省药物研究所 南京 210009;2.中国药科大学药剂学教研室 南京 210009 |
| 基金项目： | 江苏省人事厅六大人才高峰项目 |
| 摘 要： | 目的研究羟喜树碱不同制剂经大鼠静脉注射给药后的胆汁排泄特征。方法大鼠分别静脉给予羟喜树碱脂质体和羟喜树碱注射液,24 h内收集胆汁并采用HPLC进行测定。结果大鼠静脉注射羟喜树碱脂质体和羟喜树碱注射液24 h累积胆汁排泄量基本一致,羟喜树碱脂质体组平均排泄11%,羟喜树碱注射液组平均排泄13%。结论脂质体不改变羟喜树碱的胆汁排泄途径。 |
| 关 键 词： | 羟喜树碱 脂质体 胆汁排泄 |
| 收稿时间： | 2007-11-14; |
Biliary Excretion of Hydroxycamptothecin after Intravenous Injection of Its Liposomes in Rats |
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| ZHOU Wei,PING Qi-neng. Biliary Excretion of Hydroxycamptothecin after Intravenous Injection of Its Liposomes in Rats[J]. Chinese Pharmaceutical Journal, 2008, 43(17): 1339-1341 | |
| Authors: | ZHOU Wei PING Qi-neng |
| Affiliation: | 1.Nanjing University of Technology，Jiangsu Institute of Materia Medica，Nanjing 210009，China； 2. Department of Pharmaceutics，China Pharmceutical University，Nanjing 210009，China |
| Abstract: | OBJECTIVE To evaluate the biliary excretion of hydroxycamptothecin(HCPT) after intravenous injection of its liposomes in rats.METHODS HCPT liposomes and HCPT injection were administrated intravenously to rats respectively.The bile was collected at various time points for 24 h and the concentration of HCPT in the bile was measured by HPLC.RESULTS The results showed that the cumulative amount of HCPT excreted into the bile during 24 h for liposomal injection was similar with that of the conventional injection.11% of HCPT was found in the bile for the liposomes,while 13% of HCPT for the conventional injection.CONCLUSION The results showed that the biliary excretion route of HCPT wasn′t changed by liposomes. |
| Keywords: | hydroxycamptothecin liposome biliary excretion |
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