经皮腔内冠状动脉成形术前后冠心病患者血清C反应蛋白及肌钙蛋白T的变化

 目的观测经皮腔内冠状动脉成形术(PTCA)对血清C反应蛋白(CRP)及肌钙蛋白T(TnT)的影响.方法我院进行PTCA的患者86例,同期进行冠状动脉造影(CAG)的患者90例.分别于PTCA和CAG当天及术后第2天清晨采集空腹血测定CRP及TnT值.结果PTCA组术后血清CRP水平显著高于术前(P＜0.01),而术后血清TnT水平与术前比较无显著变化(P＞0.05).CAG组造影后血清CRP及TnT水平与造影前比较均无显著性差别(P＞0.05).结论PTCA明显增加血清CRP浓度,可能与PTCA治疗后局部血管炎症有关,而非心肌坏死所致.

Changes of serum C-reactive protein and troponin T in patients with coronary heart disease before and after PTCA

Objective To study the effect of percutaneous transluminal coronary angioplasty(PTCA) on serum levels of C-reactive protein (CRP) and troponin T(TnT) in patients with coronary heart disease.Methods Eighty- six patients undergoing PTCA were included in this study, and 90 patients receiving coronary angiography ( GAG) during the same period were selected as controls. Serum samples for determination of CRP and TnT were taken in the early morning of the procedure and the following early morning after the procedure. Results In patients with PTC A,CRP levels after the procedure were significantly higher than those before the procedure (P< 0.01), but the serum levels of TnT after the procedure were not significantly different from those before the procedure(P>0.05). In GAG group ,both CRP and TnT levels after angiography were not significantly different from those before angiography (P > 0.05). Conclusions PTCA leads to a detectable increase in serum levels of CRP, which is probably related to the intrinsic inflammation or tissue damage within arterial lesions treated with PTCA, but is not secondary to myocardial injury.