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| 微小RNA:肿瘤耐药治疗新靶点 | |
| 引用本文： | 陈建,王朝霞. 微小RNA:肿瘤耐药治疗新靶点[J]. 现代肿瘤医学, 2012, 20(1): 191-196. DOI: 10.3969/j.issn.1672-4992.2012.01.66 |
| 作者姓名： | 陈建 王朝霞 |
| 作者单位： | 1. 南京医科大学第一临床医学院临床医学系,江苏,南京,210029 2. 南京医科大学第二附属医院肿瘤科,江苏,南京,210000 |
| 基金项目： | 国家自然科学基金(编号:30973477);江苏省自然科学基金(编号:BK2010590);江苏省“六大人才高峰”计划(编号:09-B1-021) |
| 摘 要： | 肿瘤的多药耐药(multidrug resistance,MDR)是临床化疗失败的主要原因之一,但其耐药性机制至今尚未完全阐明.最近研究表明,微小RNA(miRNA) 对多基因表达的调控具有高效性和特异性,对靶基因的异常调控可能构成肿瘤耐药机制,是肿瘤耐药复杂性调控的重要构成部分.因此,对微小RNA与肿瘤耐药性研究具有现实意义.本文对近年来微小RNA与各种肿瘤耐药的关系及微小RNA作为肿瘤治疗潜在靶点的研究进展作一综述. |
| 关 键 词： | 微小RNA 基因表达调控 肿瘤 耐药性 |
Small RNA :new therapeutic targets for chemoresistance in cancer |
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| CHEN Jian,WANG Zhaoxia. Small RNA :new therapeutic targets for chemoresistance in cancer[J]. Journal of Modern Oncology, 2012, 20(1): 191-196. DOI: 10.3969/j.issn.1672-4992.2012.01.66 | |
| Authors: | CHEN Jian WANG Zhaoxia |
| Affiliation: | 1Department of Clinical Medicine,The First Medical College of Nanjing Medical University,Jiangsu Nanjing 210029,China;2Department of Medical Oncology,Second Affiliated Hospital of Nanjing Medical University,Jiangsu Nanjing 210000,China. |
| Abstract: | Multidrug resistant(MDR) of tumors is one of the main clinical failure of chemotherapy,but the mechanism of MDR has not yet been completely clarified.Recent studies show that small RNA(miRNA) can regulate the multi-gene expression with high efficiency and specificity,which abnormaly may be involved in the mechanism of tumor drug resistance by modulating expression of the target gene,and plays an inportant role in complex regulation of tumor resistance.Therefore,the research of the small RNA and cancer drug resistance has great practical significance.Relationship of various-tumor drug resistance with small RNA and microRNAs as potentially therapeutic targets in cancer in recent years were reviewed in this article. |
| Keywords: | miRNAs gene expression regulation neoplasms drug resistance |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |