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| 以乙酰肝素酶为靶点治疗肿瘤的研究进展 | |
| 引用本文： | 罗俊生,陈晓鹏. 以乙酰肝素酶为靶点治疗肿瘤的研究进展[J]. 现代肿瘤医学, 2012, 20(2): 422-424. DOI: 10.3969/j.issn.1672-4992.2012.02.69 |
| 作者姓名： | 罗俊生 陈晓鹏 |
| 作者单位： | 皖南医学院弋矶山医院肝胆一科,安徽,芜湖,241001 |
| 摘 要： | 乙酰肝素酶是目前发现的哺乳动物细胞中唯一能切割细胞外基质中硫酸肝素蛋白多糖侧链的导致患者肿瘤死亡的主要原因是通过肿瘤侵袭与转移引起的,不断完善肿瘤细胞侵袭转移的因素,和对其有效阻断是治内源性糖苷酶,参与许多病理及生理的过程.本文对乙酰肝素酶与肿瘤侵袭、转移的关系及其靶点的肿瘤治疗等方面进行综述,旨在为乙酰肝素酶为靶点治疗肿瘤提供一些线索. |
| 关 键 词： | 乙酰肝素酶 肿瘤 侵袭 转移 |
Research progress in heparanase as a target for the treatment of tumor |
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| LUO Junsheng,CHEN Xiaopeng. Research progress in heparanase as a target for the treatment of tumor[J]. Journal of Modern Oncology, 2012, 20(2): 422-424. DOI: 10.3969/j.issn.1672-4992.2012.02.69 | |
| Authors: | LUO Junsheng CHEN Xiaopeng |
| Affiliation: | The First Departmen of Hepatobiliary Surgery,Yijishan Hospital of Wannan Medical College,Anhui Wuhu 241001 China |
| Abstract: | Heparanase is the only mammalian heparin sulfate-degrading enzymes could cleave heparin sulfate(HS)which links to hepatan sulfate Proteoglycans(HSPGs),involved in many pathological and physiological processes.The relation of tumor invasion,metastasis and heparanase,its target of tumor therapy were reviewed to provide some clues for heparanase as a target for the treatment of tumor. |
| Keywords: | heparanase tumor invasion metastasis |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |