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Stratum corneum lipids liposomes for the topical delivery of 5-aminolevulinic acid in photodynamic therapy of skin cancer: preparation and in vitro permeation study |
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| Authors: | Bernadete R Maria Pierre Antônio C Tedesco Juliana M Marchetti M Vitória LB Bentley |
| Affiliation: | 1. Faculdade de Ciências Farmacêuticas de Ribeir?o Preto, Universidade de S?o Paulo, Av. do Café s/n, CEP 14040-903, Ribeir?o Preto, SP, Brasil 2. Faculdade de Filosofia, Ciências e Letras de Ribeir?o Preto, Universidade de S?o Paulo, Brasil |
| Abstract: | BackgroundPhotodynamic therapy (PDT) using 5-aminolevulinic acid (5-ALA) is a skin cancer therapy that still has limitations due to the low penetration of this drug into the skin. We have proposed in this work a delivery system for 5-ALA based on liposomes having lipid composition similar to the mammalian stratum corneum (SCLLs) in order to optimize its skin delivery in Photodynamic Therapy (PDT) of skin cancers. |
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