异丙酚用于辅助持续硬膜外麻醉的临床观察

目的 评价异丙酚在辅助特续硬膜外麻醉中的疗效.方法 在持续硬膜外麻醉下行腹式筋膜内子宫切除手术患者160例,随机分为P组(异丙酚组)80例,F组(氟芬合剂组)80例,F组于手术开始时静脉推注氟芬合剂1/2剂,P组于手术操作至见腹膜时静脉注射异丙酚1.5～2 mg/kg.在手术切皮、探查腹腔、手术结束3个时间点记录两组平均动脉压(MAP)、心率(HR)、脉搏氧饱和度(SpO2)、改良觉醒/镇静(OAA/S)评分,记录术中不良反应及手术者满意度.结果 探查腹腔时,P组血压(BP)、HR明显较F组稳定,(OAA/S)评分P组为1～2分,而F组为3～5分(P＜0.05);P组均无不良反应F组6例(20％)发生不良反应,满意度比较,差异具有统计学意义(P＜0.05).结论 静脉注射异丙酚在特续硬膜外麻醉中是确切有效、可行的一种辅助方法.

Clinical observation of propofol for adjuvant continuous epidural anesthesia

Objective To evaluate the clinical effect of propofol on adjuvant continuous epidural anesthesia.Methods 160 patients receiving abdominal intrafascial hysterectomy under continuous epidural anesthesia were randomly divided into propofol(P,80 cases) and innovar(F,80 cases) groups.At the beginning of operation,the half dose of innovar was intravenously administered in the group F.Propofol 1.5~2 mg/kg was intravenously administered at the peritoneum exposing during operation process in the group P.The mean arterial pressure(MAP),heart rate(HR),pulse oxygen saturation(SpO2) and modified awakening/sedation scores(OAA/S) were recorded at the 3 time points of skin incision,abdominal exploration and operation finish between the two groups.The adverse reactions and operator′s satisfaction during operation were also recorded.Results During abdominal exploration,MAP and HR in the group P were obviously more stable compared with the group F.The OAA/S scores were 1~2 in the group P and 3~5 in the group F(P<0.05).The adverse reactions in the group P were less than those in the group F.The operator′ s satisfaction showed statistical difference between group P and F(P<0.05).Conclusion Intravenous propofol for continuous epidural anesthesia is an adjuvant method with definite effect and feasibility.