Topical thermal therapy with hot packs suppresses physical inactivity-induced mechanical hyperalgesia and up-regulation of NGF |
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Authors: | Tatsuki Nakagawa Shin-ichiro Hiraga Kazue Mizumura Kiyomi Hori Noriyuki Ozaki Tomoko Koeda |
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Affiliation: | 1.Department of Functional Anatomy, Graduate School of Medical Science,Kanazawa University,Kanazawa,Japan;2.Faculty of Rehabilitation Sciences, Department of Physical Therapy,Nagoya Gakuin University,Seto,Japan;3.Department of Physical Therapy, College of Life and Health Sciences,Chubu University,Kasugai,Japan |
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Abstract: | We focused on the analgesic effect of hot packs for mechanical hyperalgesia in physically inactive rats. Male Wistar rats were randomly divided into four groups: control, physical inactivity (PI), PI + sham treatment (PI + sham), and PI + hot pack treatment (PI + hot pack) groups. Physical inactivity rats wore casts on both hind limbs in full plantar flexed position for 4 weeks. Hot pack treatment was performed for 20 min a day, 5 days a week. Although mechanical hyperalgesia and the up-regulation of NGF in the plantar skin and gastrocnemius muscle were observed in the PI and the PI + sham groups, these changes were significantly suppressed in the PI + hot pack group. The present results clearly demonstrated that hot pack treatment was effective in reducing physical inactivity-induced mechanical hyperalgesia and up-regulation of NGF in plantar skin and gastrocnemius muscle. |
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