肺腺癌T1N0M0的预后因素分析

目的：探讨肺腺癌T1N0M0患预后的病理因素与生存率的关系。方法：回顾1994年－1997年经手术治疗的肺腺癌T1N0M0 34例。观察病理学特征并随访。结果：34例病例术后平均随访时间为5．1年，5年生存率为67．7％。肿瘤直径2－3cm；中心性纤维化＞30％；有淋巴管腔的侵犯；细胞核Ⅲ级与肿瘤坏死＞50％，明显降低5年生存率。结论：研究有利于检测出转移风险较大的患，使其及时接受辅助性系统治疗。

Prognostic factors in T1N0M0 adenocarcinoma of the lung

Objective To identify pathologic prognostic factors related to survival for patients with T 1N 0M 0 adenoma of the lung.Methods 34 cases of T 1N 0M 0 adenocarcinoma of the lung surgically resected during the period in 1994-1997 were eligible in retrospective study. Pathological features of original slides from all cases were re-examined.Results The mean overall follow-up was 5.1 years, and the 5-year survival was 67.7%. Features significantly associated with decreased 5-year survival were tumor size of 2-3 cm, increased central fibrosis, nuclear grade 3, lymphatic vascular invasion, and more than 50% tumor necrosis.Conclusion These histological features may be used in the identification of patients with T 1N 0M 0 who have an increased risk of metastasis in receiving adjuvant systemic therapy.