腔隙性脑梗死和动脉粥样硬化血栓性脑梗死患者微量蛋白尿的研究

目的明确脑梗死患者微量蛋白尿(MA)阳性率及腔隙性脑梗死(lacunar infarction,LI)和动脉粥样硬化血栓性脑梗死(atherothrombotic infarction,AI)患者MA阳性率是否存在差别。方法采用竞争性放射免疫分析方法对未合并肝肾功能不全等影响尿蛋白排泄率(UAER)检测结果的83例LI和78例AI患者,以及40例原发性高血压对照者进行UAER测定。统计脑梗死患者MA的阳性率,比较合并高血压的LI、AI与高血压对照组MA阳性率。结果161例脑梗死患者MA阳性率为42·9%;单纯合并高血压病史的45例LI患者和34例AI患者MA阳性率分别为51·1%和58·8%,均高于高血压对照组(P<0·05),但两组间比较无统计学意义。结论脑梗死患者呈现MA高发率;合并高血压病史的LI和AI患者MA阳性率无差别;MA会增加脑梗死的发生风险。

The study about the microalbuminuria in lacunar infarction and atherothrombotic infarction patients

Objective To identify the frequency of microalbuminuria( MA) in cerebral infarction patients and to compare the rate of MA in lacunar infarction(LI) and atherothrombotic infarction(AI) patients.Methods We enrolled 83 LI cases and 73 AI cases without diseases such as liver or renal inadequacy which effects the outcome of urinary albumin excretion rate(UAER) and selected 40 hypertension patients consist of control group,tested all patients UAER by radioimmunoassesy methods, calculated the frequency of MA in cerebral infarction patients and compared the rate of MA in LI patients,AI patients who companying with hypertension and control group.Results The frequency of MA in cerebral infarction was 42.9%; the rate of MA in AI and LI were higher than control group respectively (P<0.05),but it wasn`t statisticlly significance between two infarct groups(P>0.05).Conclusions In cerebral infarction patients, MA is common.The rate of MA in LI and AI is no differece,MA will increase the risk of cerebral infarction.