Synthesis and Optimization of the Labeling Procedure of <Superscript>99m</Superscript>Tc-Hynic-Interleukin-2 for <Emphasis Type=Italic>In vivo</Emphasis> Imaging of Activated T lymphocytes期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Synthesis and Optimization of the Labeling Procedure of 99mTc-Hynic-Interleukin-2 for In vivo Imaging of Activated T lymphocytes

Authors:	Calogero D’Alessandria Valentina di Gialleonardo Marco Chianelli Stephen J. Mather Erik F. J. de Vries Francesco Scopinaro Rudi A. Dierck Alberto Signore

Affiliation:	(1) Nuclear Medicine Unit, 2nd Faculty of Medicine, University “Sapienza”, Rome, Italy;(2) Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands;(3) Regina Apostolorum Hospital, Albano, Rome, Italy;(4) Cancer Imaging Group, Barts and the London School of Medicine, London, UK;(5) Nuclear Medicine Unit, Sant’Andrea Hospital, Via di Grottarossa 1035-1039, 00189 Rome, Italy;

Abstract:	Introduction We have previously described the labeling of interleukin-2 (IL2) with ¹²³I and ^99mTc-N₃S. Both radiopharmaceuticals were successfully applied in humans to image several inflammatory lesions and autoimmune diseases characterized by tissue infiltrating lymphocytes expressing the IL2 receptor (CD25). However, both radiopharmaceuticals had some specific disadvantages, such as cost and time of synthesis.

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