赣榆县结核杆菌与非结核杆菌感染情况及菌株耐药分布研究

目的了解本地区典型肺结核病人结核分枝杆菌与非结核分枝杆菌感染及菌株耐药分布情况。方法收集2008年6月-2009年底我县典型肺结核病人痰标本,进行直接痰涂片检查、痰菌培养、耐药检测及结核分枝杆菌及非结核杆菌鉴定。结果 345例痰标本检出306例菌株。结核分枝杆菌288株,占94.12%,对H、R、E、S4种一线抗痨药耐药率分别为18.06%、18.40%、8.33%、21.53%;非结核分枝杆菌18株,对H、R、E、S4种一线抗痨药耐药率分别为100%、33.3.3%、33.33%、100%。结论本地区结核病人对一线抗痨药物耐药情况较为严重,非结核分枝杆菌感染比例较高,在今后工作中值得重视。

Study on Drug Resistance Distribution and Infection Situation of MTB and NTM in Ganyu Country

Objective To understand the distribution of drug resistance and infection mycobacterium tuberculosis（MTB）and non-tuberculosis mycobacteria（NTM）in this district of typical tuberculosis patients.Method Collecting the phlegm specimens of typical tuberculosis patients from 2008 to 2009.The phlegm specimens were detected by sputum smear,sputum culture,drug resistance detection,identification MTB and NTM.Results 306 microbial strains were separated from 345 sputum samples.There were 288 MTB and accounted for 94.12%,the drug resistance rates to Isoniazid,Rifampicin,Ethambutol and Streptomycin were 18.06%,18.40%,8.33% and 21.53% respectively.18 NTM accounted for 5.88% and the drug resistance rates to Isoniazid,Rifampicin,Ethambutol and Streptomycin were 100%,33.33%,33.33% and 100% respectively.Conclusions The drug resistance of this region were serious and infection of NTM was higher too,so we should attach importance to this problem in our future work.