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| 氧化石墨烯复合磷酸酯交联弹性体的制备及其用于药物缓释的研究 | |
| 引用本文： | 孙黄辉,徐志珍,夏玮,张姝,张黎伟,张文清. 氧化石墨烯复合磷酸酯交联弹性体的制备及其用于药物缓释的研究[J]. 医学教育探索, 2016, 0(4): 513-520 |
| 作者姓名： | 孙黄辉 徐志珍 夏玮 张姝 张黎伟 张文清 |
| 作者单位： | 华东理工大学上海市功能性材料化学重点实验室, 上海 200237,华东理工大学上海市功能性材料化学重点实验室, 上海 200237,华东理工大学上海市功能性材料化学重点实验室, 上海 200237,华东理工大学上海市功能性材料化学重点实验室, 上海 200237,云南林源香料有限公司, 云南玉溪 651100,华东理工大学上海市功能性材料化学重点实验室, 上海 200237 |
| 基金项目： | 云科合发（2014）5号；云南合作院士工作站资助 |
| 摘 要： | 选取亲水性较好的聚乙二醇，通过自身的相转移催化性进行环氧化，制备的环氧化产物与聚四氢呋喃磷酸酯和氧化石墨烯进行混合、交联固化，制备了可降解的磷酸酯交联材料。结果表明制备的交联材料具有良好的力学性能和降解性能，氧化石墨烯的添加影响交联材料的力学性能和降解性能。体外的药物释放测试和细胞毒性研究表明制备的聚合物作为药物释放体系具有较大的应用潜力。 |
| 关 键 词： | 氧化石墨烯 磷酸酯键 生物材料 药物载体 |
| 收稿时间： | 2016-03-28 |
Phosphoester Cross-Linked Elastomer with Graphene Oxide: Synthesis and Application as Drug Carrier |
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| SUN Huang-hui,XU Zhi-zhen,XIA Wei,ZHANG Shu,ZHANG Li-wei and ZHANG Wen-qing. Phosphoester Cross-Linked Elastomer with Graphene Oxide: Synthesis and Application as Drug Carrier[J]. Researches in Medical Education, 2016, 0(4): 513-520 | |
| Authors: | SUN Huang-hui XU Zhi-zhen XIA Wei ZHANG Shu ZHANG Li-wei ZHANG Wen-qing |
| Affiliation: | Shanghai Key Laboratory of Functional Materials Chemistry, East China University of Science and Technology, Shanghai 200237, China,Shanghai Key Laboratory of Functional Materials Chemistry, East China University of Science and Technology, Shanghai 200237, China,Shanghai Key Laboratory of Functional Materials Chemistry, East China University of Science and Technology, Shanghai 200237, China,Shanghai Key Laboratory of Functional Materials Chemistry, East China University of Science and Technology, Shanghai 200237, China,Yunnan Linyuan Perfume Co. Ltd, Yuxi 651100, Yunnan, China and Shanghai Key Laboratory of Functional Materials Chemistry, East China University of Science and Technology, Shanghai 200237, China |
| Abstract: | Based on a facile crosslinked reaction between diphosphoesters of polytetramethylene-oxide glycol (PTMEG1000-P) and diglycidyl ether of polyethylene glycol (PEG-E) prepared without any phase-transfer catalyst with graphene oxide (GO),a new series of degradable crosslinked phosphoester polymers (CPs) were prepared and characterized.The relevant experiments suggested good mechanical and degradable properties of the polymers.GO played an important role for the properties of CPs polymers,such as mechanical property and degradation rate.Drug release tests and biological cytotoxicity studies in vitro suggested that the polymers had great potential applications in drug delivery systems. |
| Keywords: | graphene oxide phosphate ester bond biomaterials drug carrier |
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