| 黄芪总黄酮抗肝损伤作用初探 |
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| 引用本文： | 汪德清,田亚平,Thomas,G,Neil,Tomlinson,Brian. 黄芪总黄酮抗肝损伤作用初探[J]. 中国中西医结合杂志, 2005, 0(Z1) |
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| 作者姓名： | 汪德清 田亚平 Thomas G Neil Tomlinson Brian |
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| 作者单位： | [1]解放军总医院生化科 [2]香港中文大学临床药理学部 [3]北京 |
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| 摘 要： | 目的研究黄芪总黄酮(total navonoids 0f Astragalus,TFA)对扑热息痛所致小鼠肝损伤的预防功效。方法观察不同剂量(0、100、300、400、500 ms/kg)扑热息痛对c57BL/6J小鼠肝脏的损伤作用,比较经1天或5天(每天2次)的TFA预处理后对扑热息痛(400 mg/kg)所致肝损伤的防护作用。结果扑热息痛对小鼠肝损伤作用具有明显的量效关系。不同剂量的TFA对扑热息痛诱导小鼠肝损伤有不同程度的防护作用,其作用强度与药物浓度成正比；TFA可增加血清中SOD活性(P＜0．05)；高剂量的TFA(100mg/kg)具有降低肝组织中脂质过氧化物质的作用；此外,在相同TFA剂量下,5天组对扑热息痛诱导小鼠肝损伤的预防作用优于1天组。结论提示TFA可预防扑热息痛诱导的肝损伤,其预防作用与其使用时间有密切关系。
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| 关 键 词： | 黄芪总黄酮 扑热息痛 肝损伤 |
Preliminary Study of Total flavonoids of Astragalus in Anti-hepatic Injury |
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| WANG De-qing TIAN Ya-ping Thomas G Neil. Preliminary Study of Total flavonoids of Astragalus in Anti-hepatic Injury[J]. Chinese journal of integrated traditional and Western medicine, 2005, 0(Z1) |
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| Authors: | WANG De-qing TIAN Ya-ping Thomas G Neil |
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| Abstract: | Objective To study the preventive effect of total flavonoids of Astragalus(TFA)on paracetamol- induced hepatic injury.Methods Different dosages of paracetamol(0,100,300,400 and 500mg/kg)on hepatic in- jury of c57BL/6J mice.The protective action induced by 400mg/kg paracetamol after 1 day or 5 days(twice/day) of TFA pretreatment in mice were compared.Results Paracetamol had obvious protection on hepatic injury of mice in a dose dependent manner.Different dosages of TFA showed protective action on mice induce... |
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| Keywords: | total flavonoids of Astragalus paracetamol hepatic injury |
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