Electrolyte metabolism in patients with periodic affective disorders during treatment with rubidium |
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Authors: | F. A. Jenner C. R. Lee C. Paschalis S. E. Hill L. Burkinshaw G. Jennings |
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Affiliation: | 1. Medical Research Council Unit for Metabolic Studies in Psychiatry, Sheffield, UK 5. Department of Medical Physics, the General Infirmary, LS1 3EX, Leeds, UK
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Abstract: | Five patients suffering from periodic affective disorders with short mood-cycles were treated with rubidium chloride, producing peak erythrocyte concentrations between 9 and 13 mmol/l. Loading with rubidium was associated with decreased total body potassium, but red-cell potassium was unchanged. Regular mood-cycling was disturbed, together with the associated body-weight changes. There was a slight extracellular "metabolic" acidosis. Electrolyte concentrations fluctuate abnormally in these patients, and two muscle biopsy specimens had very low potassium contents. |
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