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目的探讨舌肌内巨大颗粒细胞瘤的临床特点。方法对中国医科大学口腔医学院口腔颌面外科2003—2004年收治的2例舌肌内颗粒细胞瘤患者的临床资料进行回顾性分析,结合文献探讨其临床特征、组织病理学特点、诊断及治疗。结果2例患者均为年轻女性,肿物均位于舌肌内,直径约5cm,为无痛性,病程为渐进性。组织学特点为无明显被膜,瘤细胞体积较大,呈圆形,胞浆丰富,可见较多嗜伊红均质细颗粒,过碘酸-希夫(PAS)染色阳性,瘤细胞呈巢状或腺泡状生长。手术切除后均无复发。结论舌肌内颗粒细胞瘤为良性病变,切除后不易复发。

Granular cell tumor in tongue:report of two cases and review of literature

Granular cell tumor in tongue：report of two cases and review of literature. GUO Yong-feng, GE Shu-fen，WANG Xu-kai，LI Rui-wu，LU Li. Stomatological Hospital，China Medical University，Shenyang 110002，China.Abstract: Objective To report two cases of giant granular cell tumor in tongue with review of relative literature to investigate its clinical characteristics. Methods Two cases of grnular cell tumor in tongue were analyzed retrospectively and the relative literature were reviewed to investigate clinical and histopathological features, the diagnosis and treatment. Results Both cases of granular cell tumor in tongue were in young female. The course of disease was gradual without pain. It was about 5cm in diameter. The histological features of the tumor were that there was no complete capsule around tumor and tumour cells were round and relatively bigger， in which a lot of eosinophilic granules （PAS positive staining） could be seen. Numorous granular cells lived in nest form or acini form. There was no recurrence after operation. Conclusion Granular cell tumor in tongue is a benign tumor and it is not likely to recur after it is resected.